Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1004490..1005292 Replicon chromosome
Accession NZ_CP090989
Organism Staphylococcus epidermidis strain 52B

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB232_RS04820 Protein ID WP_002468490.1
Coordinates 1005113..1005292 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KB232_RS04815 Protein ID WP_002456349.1
Coordinates 1004490..1005089 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB232_RS04790 (KB232_04790) 999701..1001158 + 1458 WP_235101826.1 ABC transporter substrate-binding protein/permease -
KB232_RS04795 (KB232_04795) 1001151..1001873 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB232_RS04800 (KB232_04800) 1002388..1002525 + 138 WP_162152359.1 hypothetical protein -
KB232_RS04805 (KB232_04805) 1002735..1003865 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KB232_RS04810 (KB232_04810) 1003862..1004332 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB232_RS04815 (KB232_04815) 1004490..1005089 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KB232_RS04820 (KB232_04820) 1005113..1005292 + 180 WP_002468490.1 SAS053 family protein Toxin
KB232_RS04825 (KB232_04825) 1005448..1005852 + 405 WP_001829818.1 hypothetical protein -
KB232_RS04830 (KB232_04830) 1006037..1007422 + 1386 WP_001829862.1 class II fumarate hydratase -
KB232_RS04835 (KB232_04835) 1007783..1008607 - 825 WP_001829804.1 RluA family pseudouridine synthase -
KB232_RS04840 (KB232_04840) 1008766..1009899 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1002370..1002525 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232276 WP_002468490.1 NZ_CP090989:1005113-1005292 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232276 NZ_CP127275:c2175335-2175006 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT232276 WP_002456349.1 NZ_CP090989:1004490-1005089 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT232276 NZ_CP127275:c2175709-2175332 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References