Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 460010..460812 Replicon chromosome
Accession NZ_CP043841
Organism Staphylococcus epidermidis strain NCCP 16829

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag F1616_RS02145 Protein ID WP_002468490.1
Coordinates 460010..460189 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag F1616_RS02150 Protein ID WP_002456349.1
Coordinates 460213..460812 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1616_RS02125 455403..456536 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
F1616_RS02130 456695..457519 + 825 WP_001829804.1 RluA family pseudouridine synthase -
F1616_RS02135 457880..459265 - 1386 WP_001829862.1 class II fumarate hydratase -
F1616_RS02140 459450..459854 - 405 WP_001829818.1 hypothetical protein -
F1616_RS02145 460010..460189 - 180 WP_002468490.1 hypothetical protein Toxin
F1616_RS02150 460213..460812 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
F1616_RS02155 460970..461440 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
F1616_RS02160 461437..462567 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
F1616_RS02165 462777..462914 - 138 WP_064783702.1 hypothetical protein -
F1616_RS02170 463429..464151 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
F1616_RS02175 464144..465601 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 462777..462932 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T139343 WP_002468490.1 NZ_CP043841:c460189-460010 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T139343 NZ_CP058651:2623692-2623799 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT139343 WP_002456349.1 NZ_CP043841:c460812-460213 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT139343 NZ_CP058651:c2623645-2623579 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References