Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1689402..1690204 Replicon chromosome
Accession NZ_CP073847
Organism Staphylococcus epidermidis strain B1266875

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV50_RS07745 Protein ID WP_002468490.1
Coordinates 1689402..1689581 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV50_RS07750 Protein ID WP_002456349.1
Coordinates 1689605..1690204 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV50_RS07725 (KFV50_07735) 1684796..1685929 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV50_RS07730 (KFV50_07740) 1686088..1686911 + 824 Protein_1536 RluA family pseudouridine synthase -
KFV50_RS07735 (KFV50_07745) 1687272..1688657 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV50_RS07740 (KFV50_07750) 1688842..1689246 - 405 WP_001829818.1 hypothetical protein -
KFV50_RS07745 (KFV50_07755) 1689402..1689581 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV50_RS07750 (KFV50_07760) 1689605..1690204 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV50_RS07755 (KFV50_07765) 1690362..1690832 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV50_RS07760 (KFV50_07770) 1690829..1691959 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV50_RS07765 (KFV50_07775) 1692169..1692324 - 156 WP_001829854.1 hypothetical protein -
KFV50_RS07770 (KFV50_07780) 1692821..1693543 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV50_RS07775 (KFV50_07785) 1693536..1694993 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1692169..1692324 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200386 WP_002468490.1 NZ_CP073847:c1689581-1689402 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200386 NZ_CP097839:c130648-130250 [Shigella flexneri]
ATGCTGAAGTTTATTCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAAAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCTGCAGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAACTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200386 WP_002456349.1 NZ_CP073847:c1690204-1689605 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200386 NZ_CP097839:c130875-130648 [Shigella flexneri]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTAATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCACCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References