Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 939420..940222 Replicon chromosome
Accession NZ_CP106834
Organism Staphylococcus epidermidis strain AH6072

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag N8145_RS04545 Protein ID WP_002468490.1
Coordinates 940043..940222 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A8B5RW65
Locus tag N8145_RS04540 Protein ID WP_002470400.1
Coordinates 939420..940019 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8145_RS04515 (N8145_04515) 934631..936088 + 1458 WP_002470402.1 ABC transporter substrate-binding protein/permease -
N8145_RS04520 (N8145_04520) 936081..936803 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
N8145_RS04525 (N8145_04525) 937318..937455 + 138 WP_064783702.1 hypothetical protein -
N8145_RS04530 (N8145_04530) 937665..938795 + 1131 WP_002470398.1 tRNA epoxyqueuosine(34) reductase QueG -
N8145_RS04535 (N8145_04535) 938792..939262 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
N8145_RS04540 (N8145_04540) 939420..940019 + 600 WP_002470400.1 hypothetical protein Antitoxin
N8145_RS04545 (N8145_04545) 940043..940222 + 180 WP_002468490.1 SAS053 family protein Toxin
N8145_RS04550 (N8145_04550) 940378..940782 + 405 WP_001829818.1 hypothetical protein -
N8145_RS04555 (N8145_04555) 940967..942352 + 1386 WP_001829862.1 class II fumarate hydratase -
N8145_RS04560 (N8145_04560) 942713..943537 - 825 WP_001829804.1 RluA family pseudouridine synthase -
N8145_RS04565 (N8145_04565) 943696..944829 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 937300..937455 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T259871 WP_002468490.1 NZ_CP106834:940043-940222 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22699.58 Da        Isoelectric Point: 4.9942

>AT259871 WP_002470400.1 NZ_CP106834:939420-940019 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLSEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RW65

References