Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1564337..1565139 Replicon chromosome
Accession NZ_CP064359
Organism Staphylococcus epidermidis strain PartG-Sepidermidis-RM8376

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag IUJ42_RS07225 Protein ID WP_002468490.1
Coordinates 1564337..1564516 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag IUJ42_RS07230 Protein ID WP_002456349.1
Coordinates 1564540..1565139 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ42_RS07205 (IUJ42_07250) 1559730..1560863 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
IUJ42_RS07210 (IUJ42_07255) 1561022..1561846 + 825 WP_001829804.1 RluA family pseudouridine synthase -
IUJ42_RS07215 (IUJ42_07260) 1562207..1563592 - 1386 WP_001829862.1 class II fumarate hydratase -
IUJ42_RS07220 (IUJ42_07265) 1563777..1564181 - 405 WP_001829818.1 hypothetical protein -
IUJ42_RS07225 (IUJ42_07270) 1564337..1564516 - 180 WP_002468490.1 SAS053 family protein Toxin
IUJ42_RS07230 (IUJ42_07275) 1564540..1565139 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
IUJ42_RS07235 (IUJ42_07280) 1565297..1565767 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IUJ42_RS07240 (IUJ42_07285) 1565764..1566894 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
IUJ42_RS07245 (IUJ42_07290) 1567103..1567258 - 156 WP_001829854.1 hypothetical protein -
IUJ42_RS07250 (IUJ42_07295) 1567755..1568477 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
IUJ42_RS07255 (IUJ42_07300) 1568470..1569927 - 1458 WP_011082742.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1567103..1567258 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T180910 WP_002468490.1 NZ_CP064359:c1564516-1564337 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T180910 NZ_CP085792:c775840-775442 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT180910 WP_002456349.1 NZ_CP064359:c1565139-1564540 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT180910 NZ_CP085792:c776067-775840 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References