Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1238062..1238864 Replicon chromosome
Accession NZ_CP121507
Organism Staphylococcus epidermidis strain 23DSE01

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag QA588_RS05900 Protein ID WP_002468490.1
Coordinates 1238685..1238864 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag QA588_RS05895 Protein ID WP_002456349.1
Coordinates 1238062..1238661 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA588_RS05870 1233273..1234730 + 1458 WP_278269197.1 ABC transporter substrate-binding protein/permease -
QA588_RS05875 1234723..1235445 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
QA588_RS05880 1235942..1236097 + 156 WP_001829854.1 hypothetical protein -
QA588_RS05885 1236307..1237437 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
QA588_RS05890 1237434..1237904 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QA588_RS05895 1238062..1238661 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
QA588_RS05900 1238685..1238864 + 180 WP_002468490.1 SAS053 family protein Toxin
QA588_RS05905 1239020..1239424 + 405 WP_001829818.1 hypothetical protein -
QA588_RS05910 1239609..1240994 + 1386 WP_001829862.1 class II fumarate hydratase -
QA588_RS05915 1241355..1242179 - 825 WP_001829804.1 RluA family pseudouridine synthase -
QA588_RS05920 1242338..1243471 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1235942..1236097 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T276382 WP_002468490.1 NZ_CP121507:1238685-1238864 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT276382 WP_002456349.1 NZ_CP121507:1238062-1238661 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References