Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 956201..957003 Replicon chromosome
Accession NZ_CP090575
Organism Staphylococcus epidermidis strain 11H

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB225_RS04595 Protein ID WP_002468490.1
Coordinates 956824..957003 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KB225_RS04590 Protein ID WP_002456349.1
Coordinates 956201..956800 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB225_RS04565 (KB225_04565) 951412..952869 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KB225_RS04570 (KB225_04570) 952862..953584 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB225_RS04575 (KB225_04575) 954081..954236 + 156 WP_001829854.1 hypothetical protein -
KB225_RS04580 (KB225_04580) 954446..955576 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KB225_RS04585 (KB225_04585) 955573..956043 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB225_RS04590 (KB225_04590) 956201..956800 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KB225_RS04595 (KB225_04595) 956824..957003 + 180 WP_002468490.1 SAS053 family protein Toxin
KB225_RS04600 (KB225_04600) 957159..957563 + 405 WP_001829818.1 hypothetical protein -
KB225_RS04605 (KB225_04605) 957748..959133 + 1386 WP_001829862.1 class II fumarate hydratase -
KB225_RS04610 (KB225_04610) 959494..960318 - 825 WP_001829804.1 RluA family pseudouridine synthase -
KB225_RS04615 (KB225_04615) 960477..961610 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 954081..954236 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T231258 WP_002468490.1 NZ_CP090575:956824-957003 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T231258 NZ_CP126169:c3053636-3053277 [Rahnella bonaserana]
GTGTGGATAATTAATACGACAGAGAGATTTGATGACTGGTTCGATAGTCTCGACCATGTTGATCAGGCGAGTGTGCTGGC
TTTGGCGATCGTCTTAAAAGACAAAGGCCCTGCGTTATCCAGGCCTTACGCAGATACAGTGAATAACTCCTGTCATCGTA
ATATGAAAGAACTGCGTATACTGAGTAAAGGCGAACCCATCCGGGCGTTTTTTGCTTTTGACCCTTTACGCAGGGGTATA
TTGCTTTGCGCGGGACACAAAGCCGGAAATGAAAAACGATTTTATAATGTCATGATACCGGTTGCCGATAATGAATTTTC
CCGGCACCTGAATACGATAAAAGAAAAGGAATTGCCCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT231258 WP_002456349.1 NZ_CP090575:956201-956800 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT231258 NZ_CP126169:c3053277-3052975 [Rahnella bonaserana]
ATGAGCAGAACCCTTGAAGAGTTACTGGCATCGGTAAAACCTGAGGTTGCCGCGCAGGCACAGGCAATGGCCGCCGATAT
TTTGATCACGATTGAGCTGGCCGAACTGCGTGAAAGAATGAATAAAACACAATGTGAGTTGGCTGAAACGTTGGGCATTA
AACAGCCGACAGTTGCTGGTATGGAAAAGCCGGGCCGTGACCTAAAATTGTCGACGTTGAAGCGGTATGTAGAAGCAGCT
GGTGGCAAGCTGCGATTGGAAATCGATCTGCCGGACGGCAGTCATTTTGGATTTGCTATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References