Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 1610816..1611618 | Replicon | chromosome |
Accession | NZ_LR134536 | ||
Organism | Staphylococcus epidermidis strain NCTC13924 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | Q5HN83 |
Locus tag | EL299_RS07750 | Protein ID | WP_002468490.1 |
Coordinates | 1610816..1610995 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | Q5HN82 |
Locus tag | EL299_RS07755 | Protein ID | WP_002456349.1 |
Coordinates | 1611019..1611618 (-) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EL299_RS07730 | 1606210..1607343 | - | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
EL299_RS07735 | 1607502..1608325 | + | 824 | Protein_1468 | RluA family pseudouridine synthase | - |
EL299_RS07740 | 1608686..1610071 | - | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
EL299_RS07745 | 1610256..1610660 | - | 405 | WP_001829818.1 | hypothetical protein | - |
EL299_RS07750 | 1610816..1610995 | - | 180 | WP_002468490.1 | hypothetical protein | Toxin |
EL299_RS07755 | 1611019..1611618 | - | 600 | WP_002456349.1 | glucosamine-6-phosphate isomerase | Antitoxin |
EL299_RS07760 | 1611776..1612246 | - | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
EL299_RS07765 | 1612243..1613373 | - | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
EL299_RS14140 | 1613583..1613738 | - | 156 | WP_001829854.1 | hypothetical protein | - |
EL299_RS07770 | 1614235..1614957 | - | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
EL299_RS07775 | 1614950..1616407 | - | 1458 | WP_002440300.1 | ABC transporter substrate-binding protein/permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 1613583..1613738 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T288031 WP_002468490.1 NZ_LR134536:c1610995-1610816 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
Antitoxin
Download Length: 200 a.a. Molecular weight: 22709.62 Da Isoelectric Point: 4.9942
>AT288031 WP_002456349.1 NZ_LR134536:c1611618-1611019 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HY44 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E9LUD0 |