Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1610816..1611618 Replicon chromosome
Accession NZ_LR134536
Organism Staphylococcus epidermidis strain NCTC13924

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag EL299_RS07750 Protein ID WP_002468490.1
Coordinates 1610816..1610995 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag EL299_RS07755 Protein ID WP_002456349.1
Coordinates 1611019..1611618 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL299_RS07730 1606210..1607343 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
EL299_RS07735 1607502..1608325 + 824 Protein_1468 RluA family pseudouridine synthase -
EL299_RS07740 1608686..1610071 - 1386 WP_001829862.1 class II fumarate hydratase -
EL299_RS07745 1610256..1610660 - 405 WP_001829818.1 hypothetical protein -
EL299_RS07750 1610816..1610995 - 180 WP_002468490.1 hypothetical protein Toxin
EL299_RS07755 1611019..1611618 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
EL299_RS07760 1611776..1612246 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL299_RS07765 1612243..1613373 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
EL299_RS14140 1613583..1613738 - 156 WP_001829854.1 hypothetical protein -
EL299_RS07770 1614235..1614957 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
EL299_RS07775 1614950..1616407 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1613583..1613738 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T288031 WP_002468490.1 NZ_LR134536:c1610995-1610816 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT288031 WP_002456349.1 NZ_LR134536:c1611618-1611019 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References