Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1068235..1069037 Replicon chromosome
Accession NZ_LR735437
Organism Staphylococcus epidermidis strain none isolate Se_BPH0723

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag GOZ17_RS05265 Protein ID WP_002468490.1
Coordinates 1068858..1069037 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag GOZ17_RS05260 Protein ID WP_002456349.1
Coordinates 1068235..1068834 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ17_RS05235 1063446..1064903 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
GOZ17_RS05240 1064896..1065618 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
GOZ17_RS05245 1066115..1066270 + 156 WP_001829854.1 hypothetical protein -
GOZ17_RS05250 1066480..1067610 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
GOZ17_RS05255 1067607..1068077 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GOZ17_RS05260 1068235..1068834 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
GOZ17_RS05265 1068858..1069037 + 180 WP_002468490.1 hypothetical protein Toxin
GOZ17_RS05270 1069193..1069597 + 405 WP_001829818.1 hypothetical protein -
GOZ17_RS05275 1069782..1071167 + 1386 WP_001829862.1 class II fumarate hydratase -
GOZ17_RS05280 1071528..1072352 - 825 WP_001829804.1 RluA family pseudouridine synthase -
GOZ17_RS05285 1072511..1073644 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1066115..1066270 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T288887 WP_002468490.1 NZ_LR735437:1068858-1069037 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT288887 WP_002456349.1 NZ_LR735437:1068235-1068834 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References