Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1446456..1447258 Replicon chromosome
Accession NC_002976
Organism Staphylococcus epidermidis RP62A

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag SERP_RS06885 Protein ID WP_002468490.1
Coordinates 1446456..1446635 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag SERP_RS06890 Protein ID WP_002456349.1
Coordinates 1446659..1447258 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERP_RS06865 1441849..1442982 - 1134 WP_010959201.1 GAF domain-containing sensor histidine kinase -
SERP_RS06870 1443141..1443965 + 825 WP_001829804.1 RluA family pseudouridine synthase -
SERP_RS06875 1444326..1445711 - 1386 WP_001829862.1 class II fumarate hydratase -
SERP_RS06880 1445896..1446300 - 405 WP_001829818.1 hypothetical protein -
SERP_RS06885 1446456..1446635 - 180 WP_002468490.1 hypothetical protein Toxin
SERP_RS06890 1446659..1447258 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
SERP_RS06895 1447416..1447886 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SERP_RS06900 1447883..1449013 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
SERP_RS13995 1449223..1449378 - 156 WP_001829854.1 hypothetical protein -
SERP_RS06910 1449875..1450597 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
SERP_RS06915 1450590..1452047 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1449223..1449378 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T20628 WP_002468490.1 NC_002976:c1446635-1446456 [Staphylococcus epidermidis RP62A]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T20628 NC_002976:c1446635-1446456 [Staphylococcus epidermidis RP62A]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT20628 WP_002456349.1 NC_002976:c1447258-1446659 [Staphylococcus epidermidis RP62A]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT20628 NC_002976:c1447258-1446659 [Staphylococcus epidermidis RP62A]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References