200480

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1021740..1022542 Replicon chromosome
Accession NZ_CP073895
Organism Staphylococcus epidermidis strain V1937538

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV38_RS05430 Protein ID WP_002468490.1
Coordinates 1022363..1022542 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV38_RS05425 Protein ID WP_002456349.1
Coordinates 1021740..1022339 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV38_RS05400 (KFV38_05400) 1016951..1018408 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV38_RS05405 (KFV38_05405) 1018401..1019123 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV38_RS05410 (KFV38_05410) 1019620..1019775 + 156 WP_001829854.1 hypothetical protein -
KFV38_RS05415 (KFV38_05415) 1019985..1021115 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV38_RS05420 (KFV38_05420) 1021112..1021582 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV38_RS05425 (KFV38_05425) 1021740..1022339 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV38_RS05430 (KFV38_05430) 1022363..1022542 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV38_RS05435 (KFV38_05435) 1022698..1023102 + 405 WP_001829818.1 hypothetical protein -
KFV38_RS05440 (KFV38_05440) 1023287..1024672 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV38_RS05445 (KFV38_05445) 1025033..1025856 - 824 Protein_1030 RluA family pseudouridine synthase -
KFV38_RS05450 (KFV38_05450) 1026015..1027148 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1019620..1019775 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200480 WP_002468490.1 NZ_CP073895:1022363-1022542 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200480 NZ_CP073895:1022363-1022542 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200480 WP_002456349.1 NZ_CP073895:1021740-1022339 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200480 NZ_CP073895:1021740-1022339 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References