183130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 611808..612610 Replicon chromosome
Accession NZ_CP065656
Organism Staphylococcus epidermidis strain FDAARGOS_913

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag I6G70_RS03235 Protein ID WP_002468490.1
Coordinates 612431..612610 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag I6G70_RS03230 Protein ID WP_002456349.1
Coordinates 611808..612407 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G70_RS03205 607020..608477 + 1458 WP_011082742.1 ABC transporter substrate-binding protein/permease -
I6G70_RS03210 608470..609192 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
I6G70_RS03215 609689..609844 + 156 WP_001829854.1 hypothetical protein -
I6G70_RS03220 610053..611183 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
I6G70_RS03225 611180..611650 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I6G70_RS03230 611808..612407 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
I6G70_RS03235 612431..612610 + 180 WP_002468490.1 hypothetical protein Toxin
I6G70_RS03240 612766..613170 + 405 WP_001829818.1 hypothetical protein -
I6G70_RS03245 613355..614740 + 1386 WP_001829862.1 class II fumarate hydratase -
I6G70_RS03250 615101..615925 - 825 WP_001829804.1 RluA family pseudouridine synthase -
I6G70_RS03255 616084..617217 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 609689..609844 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T183130 WP_002468490.1 NZ_CP065656:612431-612610 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T183130 NZ_CP086678:3149064-3149399 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT183130 WP_002456349.1 NZ_CP065656:611808-612407 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT183130 NZ_CP086678:3148816-3149064 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References