Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1690847..1691649 Replicon chromosome
Accession NZ_CP073859
Organism Staphylococcus epidermidis strain B1275857

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV44_RS07775 Protein ID WP_002468490.1
Coordinates 1690847..1691026 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV44_RS07780 Protein ID WP_002456349.1
Coordinates 1691050..1691649 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV44_RS07755 (KFV44_07765) 1686241..1687374 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV44_RS07760 (KFV44_07770) 1687533..1688356 + 824 Protein_1546 RluA family pseudouridine synthase -
KFV44_RS07765 (KFV44_07775) 1688717..1690102 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV44_RS07770 (KFV44_07780) 1690287..1690691 - 405 WP_001829818.1 hypothetical protein -
KFV44_RS07775 (KFV44_07785) 1690847..1691026 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV44_RS07780 (KFV44_07790) 1691050..1691649 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV44_RS07785 (KFV44_07795) 1691807..1692277 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV44_RS07790 (KFV44_07800) 1692274..1693404 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV44_RS07795 (KFV44_07805) 1693614..1693751 - 138 WP_064783702.1 hypothetical protein -
KFV44_RS07800 (KFV44_07810) 1694266..1694988 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV44_RS07805 (KFV44_07815) 1694981..1696438 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1693614..1693769 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200411 WP_002468490.1 NZ_CP073859:c1691026-1690847 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200411 NZ_CP097846:c1027342-1026923 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200411 WP_002456349.1 NZ_CP073859:c1691649-1691050 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200411 NZ_CP097846:c1027578-1027342 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References