Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1690690..1691492 Replicon chromosome
Accession NZ_CP073869
Organism Staphylococcus epidermidis strain B1279591

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV51_RS07825 Protein ID WP_002468490.1
Coordinates 1690690..1690869 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV51_RS07830 Protein ID WP_002456349.1
Coordinates 1690893..1691492 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV51_RS07805 (KFV51_07845) 1686084..1687217 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV51_RS07810 (KFV51_07850) 1687376..1688199 + 824 Protein_1536 RluA family pseudouridine synthase -
KFV51_RS07815 (KFV51_07855) 1688560..1689945 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV51_RS07820 (KFV51_07860) 1690130..1690534 - 405 WP_001829818.1 hypothetical protein -
KFV51_RS07825 (KFV51_07865) 1690690..1690869 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV51_RS07830 (KFV51_07870) 1690893..1691492 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV51_RS07835 (KFV51_07875) 1691650..1692120 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV51_RS07840 (KFV51_07880) 1692117..1693247 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV51_RS07845 (KFV51_07885) 1693457..1693612 - 156 WP_001829854.1 hypothetical protein -
KFV51_RS07850 (KFV51_07890) 1694109..1694831 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV51_RS07855 (KFV51_07895) 1694824..1696281 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1693457..1693612 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200431 WP_002468490.1 NZ_CP073869:c1690869-1690690 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200431 NZ_CP097870:3677118-3677516 [Thauera sp. GDN1]
ATGCTCAAGTACCTGCTCGACACCAACATCGTGATCTACACGGTGAAGAACAAGCCGGCCCAGGTCCGCGAACGCTTCCG
TCAGCACGGCGGGCAGATGGCGATCTCCAGCGTCACCCTGGGCGAGCTCGTGTTCGGCGCCGAGCGTTCCACCCGCCCCG
AGGCGAACCTGGCCGTCGTCGAGGGCTTTGTCGCGCGTGTCGATACCCTGGACTTCGACCCCGCCGCCGCCCACCACTTC
GGCCAGATCCGCGCCGAACTCTACCGGGCCGGCCGCCCGATCGGCCCCTACGACATGATGATCGCCGCGCACGCACGCTC
GCGAGGACTCATCCTGGTCACCAACAACACGTCCGAATTCGAGCGCGTCGCCGGCCTGCGGCTGGAGAACTGGGCCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200431 WP_002456349.1 NZ_CP073869:c1691492-1690893 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200431 NZ_CP097870:3676876-3677115 [Thauera sp. GDN1]
ATGACGAGTTCCTCGCAAACCACCGTCTTCCGCAGCAACAAGACGCAGGCCGTTCGCCTGCCGAAGGCGCTCGAACTGCC
CGAGTCGGTCAAGAAGGTCACGATCACCGCAATCGGCAATACCCGCGTCATCGCACCCGTCGAGGCAAGCTGGGACGCCT
GGTTCGACGGCCCCGACGTCAGCGCCGACTTCATGGTCGCGCGCGAGCAGCCCGACGACCAGGCCCGCGAGGCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References