Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1727984..1728786 Replicon chromosome
Accession NZ_CP073835
Organism Staphylococcus epidermidis strain B1230143

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV52_RS08240 Protein ID WP_002468490.1
Coordinates 1727984..1728163 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV52_RS08245 Protein ID WP_002456349.1
Coordinates 1728187..1728786 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV52_RS08220 (KFV52_08230) 1723378..1724511 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV52_RS08225 (KFV52_08235) 1724670..1725493 + 824 Protein_1601 RluA family pseudouridine synthase -
KFV52_RS08230 (KFV52_08240) 1725854..1727239 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV52_RS08235 (KFV52_08245) 1727424..1727828 - 405 WP_001829818.1 hypothetical protein -
KFV52_RS08240 (KFV52_08250) 1727984..1728163 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV52_RS08245 (KFV52_08255) 1728187..1728786 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV52_RS08250 (KFV52_08260) 1728944..1729414 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV52_RS08255 (KFV52_08265) 1729411..1730541 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV52_RS08260 (KFV52_08270) 1730751..1730906 - 156 WP_001829854.1 hypothetical protein -
KFV52_RS08265 (KFV52_08275) 1731403..1732125 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV52_RS08270 (KFV52_08280) 1732118..1733575 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1730751..1730906 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200361 WP_002468490.1 NZ_CP073835:c1728163-1727984 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200361 NZ_CP097834:4069905-4070219 [Shigella flexneri]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200361 WP_002456349.1 NZ_CP073835:c1728786-1728187 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200361 NZ_CP097834:4070216-4070632 [Shigella flexneri]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References