Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1690850..1691652 Replicon chromosome
Accession NZ_CP073872
Organism Staphylococcus epidermidis strain B1282731

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV34_RS07825 Protein ID WP_002468490.1
Coordinates 1690850..1691029 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV34_RS07830 Protein ID WP_002456349.1
Coordinates 1691053..1691652 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV34_RS07805 (KFV34_07815) 1686244..1687377 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV34_RS07810 (KFV34_07820) 1687536..1688359 + 824 Protein_1536 RluA family pseudouridine synthase -
KFV34_RS07815 (KFV34_07825) 1688720..1690105 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV34_RS07820 (KFV34_07830) 1690290..1690694 - 405 WP_001829818.1 hypothetical protein -
KFV34_RS07825 (KFV34_07835) 1690850..1691029 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV34_RS07830 (KFV34_07840) 1691053..1691652 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV34_RS07835 (KFV34_07845) 1691810..1692280 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV34_RS07840 (KFV34_07850) 1692277..1693407 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV34_RS07845 (KFV34_07855) 1693617..1693772 - 156 WP_001829854.1 hypothetical protein -
KFV34_RS07850 (KFV34_07860) 1694269..1694991 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV34_RS07855 (KFV34_07865) 1694984..1696441 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1693617..1693772 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200436 WP_002468490.1 NZ_CP073872:c1691029-1690850 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200436 NZ_CP097881:183643-183750 [Escherichia coli str. K-12 substr. MG1655]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200436 WP_002456349.1 NZ_CP073872:c1691652-1691053 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200436 NZ_CP097881:c183595-183529 [Escherichia coli str. K-12 substr. MG1655]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References