Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 1690850..1691652 | Replicon | chromosome |
Accession | NZ_CP073872 | ||
Organism | Staphylococcus epidermidis strain B1282731 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | Q5HN83 |
Locus tag | KFV34_RS07825 | Protein ID | WP_002468490.1 |
Coordinates | 1690850..1691029 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | Q5HN82 |
Locus tag | KFV34_RS07830 | Protein ID | WP_002456349.1 |
Coordinates | 1691053..1691652 (-) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFV34_RS07805 (KFV34_07815) | 1686244..1687377 | - | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
KFV34_RS07810 (KFV34_07820) | 1687536..1688359 | + | 824 | Protein_1536 | RluA family pseudouridine synthase | - |
KFV34_RS07815 (KFV34_07825) | 1688720..1690105 | - | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
KFV34_RS07820 (KFV34_07830) | 1690290..1690694 | - | 405 | WP_001829818.1 | hypothetical protein | - |
KFV34_RS07825 (KFV34_07835) | 1690850..1691029 | - | 180 | WP_002468490.1 | SAS053 family protein | Toxin |
KFV34_RS07830 (KFV34_07840) | 1691053..1691652 | - | 600 | WP_002456349.1 | glucosamine-6-phosphate isomerase | Antitoxin |
KFV34_RS07835 (KFV34_07845) | 1691810..1692280 | - | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
KFV34_RS07840 (KFV34_07850) | 1692277..1693407 | - | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
KFV34_RS07845 (KFV34_07855) | 1693617..1693772 | - | 156 | WP_001829854.1 | hypothetical protein | - |
KFV34_RS07850 (KFV34_07860) | 1694269..1694991 | - | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
KFV34_RS07855 (KFV34_07865) | 1694984..1696441 | - | 1458 | WP_002440300.1 | ABC transporter substrate-binding protein/permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 1693617..1693772 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T200436 WP_002468490.1 NZ_CP073872:c1691029-1690850 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
>T200436 NZ_CP097881:183643-183750 [Escherichia coli str. K-12 substr. MG1655]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22709.62 Da Isoelectric Point: 4.9942
>AT200436 WP_002456349.1 NZ_CP073872:c1691652-1691053 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
>AT200436 NZ_CP097881:c183595-183529 [Escherichia coli str. K-12 substr. MG1655]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HY44 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E9LUD0 |