Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1024244..1025046 Replicon chromosome
Accession NZ_CP073841
Organism Staphylococcus epidermidis strain B1264787

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV40_RS05440 Protein ID WP_002468490.1
Coordinates 1024867..1025046 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV40_RS05435 Protein ID WP_002456349.1
Coordinates 1024244..1024843 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV40_RS05410 (KFV40_05410) 1019455..1020912 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV40_RS05415 (KFV40_05415) 1020905..1021627 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV40_RS05420 (KFV40_05420) 1022124..1022279 + 156 WP_001829854.1 hypothetical protein -
KFV40_RS05425 (KFV40_05425) 1022489..1023619 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV40_RS05430 (KFV40_05430) 1023616..1024086 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV40_RS05435 (KFV40_05435) 1024244..1024843 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV40_RS05440 (KFV40_05440) 1024867..1025046 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV40_RS05445 (KFV40_05445) 1025202..1025606 + 405 WP_001829818.1 hypothetical protein -
KFV40_RS05450 (KFV40_05450) 1025791..1027176 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV40_RS05455 (KFV40_05455) 1027537..1028360 - 824 Protein_1032 RluA family pseudouridine synthase -
KFV40_RS05460 (KFV40_05460) 1028519..1029652 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1022124..1022279 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200380 WP_002468490.1 NZ_CP073841:1024867-1025046 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200380 NZ_CP073841:1024867-1025046 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200380 WP_002456349.1 NZ_CP073841:1024244-1024843 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200380 NZ_CP073841:1024244-1024843 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References