Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1024310..1025112 Replicon chromosome
Accession NZ_CP073900
Organism Staphylococcus epidermidis strain V1949610

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV25_RS05440 Protein ID WP_002468490.1
Coordinates 1024933..1025112 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV25_RS05435 Protein ID WP_002456349.1
Coordinates 1024310..1024909 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV25_RS05410 (KFV25_05410) 1019521..1020978 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV25_RS05415 (KFV25_05415) 1020971..1021693 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV25_RS05420 (KFV25_05420) 1022190..1022345 + 156 WP_001829854.1 hypothetical protein -
KFV25_RS05425 (KFV25_05425) 1022555..1023685 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV25_RS05430 (KFV25_05430) 1023682..1024152 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV25_RS05435 (KFV25_05435) 1024310..1024909 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV25_RS05440 (KFV25_05440) 1024933..1025112 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV25_RS05445 (KFV25_05445) 1025268..1025672 + 405 WP_001829818.1 hypothetical protein -
KFV25_RS05450 (KFV25_05450) 1025857..1027242 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV25_RS05455 (KFV25_05455) 1027603..1028426 - 824 Protein_1032 RluA family pseudouridine synthase -
KFV25_RS05460 (KFV25_05460) 1028585..1029718 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1022190..1022345 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200490 WP_002468490.1 NZ_CP073900:1024933-1025112 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200490 NZ_CP097883:649276-649590 [Escherichia coli str. K-12 substr. MG1655]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200490 WP_002456349.1 NZ_CP073900:1024310-1024909 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200490 NZ_CP097883:649587-650003 [Escherichia coli str. K-12 substr. MG1655]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References