240090

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1012299..1013101 Replicon chromosome
Accession NZ_CP094728
Organism Staphylococcus epidermidis strain IVB6213

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MUA98_RS04865 Protein ID WP_002468490.1
Coordinates 1012922..1013101 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MUA98_RS04860 Protein ID WP_002456349.1
Coordinates 1012299..1012898 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA98_RS04835 (MUA98_04810) 1007510..1008967 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MUA98_RS04840 (MUA98_04815) 1008960..1009682 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MUA98_RS04845 (MUA98_04820) 1010197..1010334 + 138 WP_064783702.1 hypothetical protein -
MUA98_RS04850 (MUA98_04825) 1010544..1011674 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA98_RS04855 (MUA98_04830) 1011671..1012141 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA98_RS04860 (MUA98_04835) 1012299..1012898 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MUA98_RS04865 (MUA98_04840) 1012922..1013101 + 180 WP_002468490.1 SAS053 family protein Toxin
MUA98_RS04870 (MUA98_04845) 1013257..1013661 + 405 WP_001829818.1 hypothetical protein -
MUA98_RS04875 (MUA98_04850) 1013846..1015231 + 1386 WP_001829862.1 class II fumarate hydratase -
MUA98_RS04880 (MUA98_04855) 1015592..1016416 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MUA98_RS04885 (MUA98_04860) 1016575..1017708 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1010179..1010334 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T240090 WP_002468490.1 NZ_CP094728:1012922-1013101 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T240090 NZ_LS483500:c1053016-1052282 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT240090 WP_002456349.1 NZ_CP094728:1012299-1012898 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT240090 NZ_LS483500:c1053715-1053116 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References