232127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 926054..926856 Replicon chromosome
Accession NZ_CP090912
Organism Staphylococcus epidermidis strain 44

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB228_RS04425 Protein ID WP_002468490.1
Coordinates 926677..926856 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KB228_RS04420 Protein ID WP_002456349.1
Coordinates 926054..926653 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB228_RS04395 (KB228_04395) 921265..922722 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KB228_RS04400 (KB228_04400) 922715..923437 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB228_RS04405 (KB228_04405) 923952..924089 + 138 WP_162187855.1 hypothetical protein -
KB228_RS04410 (KB228_04410) 924299..925429 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KB228_RS04415 (KB228_04415) 925426..925896 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB228_RS04420 (KB228_04420) 926054..926653 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KB228_RS04425 (KB228_04425) 926677..926856 + 180 WP_002468490.1 SAS053 family protein Toxin
KB228_RS04430 (KB228_04430) 927012..927416 + 405 WP_001829818.1 hypothetical protein -
KB228_RS04435 (KB228_04435) 927601..928986 + 1386 WP_234963962.1 class II fumarate hydratase -
KB228_RS04440 (KB228_04440) 929347..930171 - 825 WP_001829804.1 RluA family pseudouridine synthase -
KB228_RS04445 (KB228_04445) 930330..931463 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 923934..924089 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232127 WP_002468490.1 NZ_CP090912:926677-926856 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232127 NZ_CP127257:c42015-41635 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT232127 WP_002456349.1 NZ_CP090912:926054-926653 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT232127 NZ_CP127257:c42236-42015 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References