Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1499473..1500275 Replicon chromosome
Accession NZ_CP093210
Organism Staphylococcus epidermidis strain TSM-50

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU50_RS06865 Protein ID WP_002468490.1
Coordinates 1499473..1499652 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU50_RS06870 Protein ID WP_002456349.1
Coordinates 1499676..1500275 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU50_RS06845 (MNU50_06830) 1494866..1495999 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
MNU50_RS06850 (MNU50_06835) 1496158..1496982 + 825 WP_001829804.1 RluA family pseudouridine synthase -
MNU50_RS06855 (MNU50_06840) 1497343..1498728 - 1386 WP_001829862.1 class II fumarate hydratase -
MNU50_RS06860 (MNU50_06845) 1498913..1499317 - 405 WP_001829818.1 hypothetical protein -
MNU50_RS06865 (MNU50_06850) 1499473..1499652 - 180 WP_002468490.1 SAS053 family protein Toxin
MNU50_RS06870 (MNU50_06855) 1499676..1500275 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU50_RS06875 (MNU50_06860) 1500433..1500903 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU50_RS06880 (MNU50_06865) 1500900..1502030 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU50_RS06885 (MNU50_06870) 1502240..1502377 - 138 WP_064783702.1 hypothetical protein -
MNU50_RS06890 (MNU50_06875) 1502892..1503614 - 723 WP_254105064.1 amino acid ABC transporter ATP-binding protein -
MNU50_RS06895 (MNU50_06880) 1503607..1505064 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1502240..1502395 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237801 WP_002468490.1 NZ_CP093210:c1499652-1499473 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237801 NZ_LR882963:2014151-2014486 [Planktothrix agardhii]
ATGAATTTTTGGATTGATGCCCAACTTCCTCCAAGTTTAGCTAATTGGTTGGTCGAAACTTTTAATGTTAATGCTACGGC
TATTAGAGATTTGGGGTTACGAGATGCTGAAGATATAGAGATTTTCAATGCTGCCAGGAACCCAGGGACGGTTATTGTTA
GTAAAGACAGCGATTTTGTGGAGTTAGTTACTCGTTTAGGAACTCCTCCTCAAATTCTCTGGTTGACTTGTGGGAATGTT
ACTAACCGAAACCTGCGACTGATTTTGAGCAATACTTTTGCCGAAGCATTACCAATGCTAGAAGCTGGAGAAGCGATTGT
GGAAATTAGCGATTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237801 WP_002456349.1 NZ_CP093210:c1500275-1499676 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237801 NZ_LR882963:2013924-2014154 [Planktothrix agardhii]
ATGACTGCAAAAAGCTTGCTTAATCGAATTACTTATAACCCCAGGCAATGTGGAGGGAGACCTTGCATTCGAGGAATGCG
AATTCGCGTTTCTGATATTTTAGAGATGCTGGCAGAAAATGTTAGTAGTGGGGAAATTTTAGAAGATTTCCCCGACTTGG
AGGCGGAGGATATTCAAGCTTGTTTGTTGTTTGCTGCCCGACGAACTAATATTCCTAAATTAACAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References