237759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1566339..1567141 Replicon chromosome
Accession NZ_CP093181
Organism Staphylococcus epidermidis strain TMDU-265

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU40_RS07500 Protein ID WP_002468490.1
Coordinates 1566339..1566518 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU40_RS07505 Protein ID WP_002456349.1
Coordinates 1566542..1567141 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU40_RS07480 (MNU40_07485) 1561732..1562865 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
MNU40_RS07485 (MNU40_07490) 1563024..1563848 + 825 WP_254104734.1 RluA family pseudouridine synthase -
MNU40_RS07490 (MNU40_07495) 1564209..1565594 - 1386 WP_001829862.1 class II fumarate hydratase -
MNU40_RS07495 (MNU40_07500) 1565779..1566183 - 405 WP_001829818.1 hypothetical protein -
MNU40_RS07500 (MNU40_07505) 1566339..1566518 - 180 WP_002468490.1 SAS053 family protein Toxin
MNU40_RS07505 (MNU40_07510) 1566542..1567141 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU40_RS07510 (MNU40_07515) 1567299..1567769 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU40_RS07515 (MNU40_07520) 1567766..1568896 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU40_RS07520 (MNU40_07525) 1569106..1569261 - 156 WP_001829854.1 hypothetical protein -
MNU40_RS07525 (MNU40_07530) 1569758..1570480 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU40_RS07530 (MNU40_07535) 1570473..1571930 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1569106..1569261 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237759 WP_002468490.1 NZ_CP093181:c1566518-1566339 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237759 NZ_LR882500:c3113970-3113614 [Mycobacterium tuberculosis variant microti]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237759 WP_002456349.1 NZ_CP093181:c1567141-1566542 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237759 NZ_LR882500:c3114184-3113954 [Mycobacterium tuberculosis variant microti]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References