237777

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1058571..1059373 Replicon chromosome
Accession NZ_CP093196
Organism Staphylococcus epidermidis strain TMDU-2014-62

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU55_RS05215 Protein ID WP_002468490.1
Coordinates 1059194..1059373 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU55_RS05210 Protein ID WP_002456349.1
Coordinates 1058571..1059170 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU55_RS05185 (MNU55_05185) 1053782..1055239 + 1458 WP_254105994.1 ABC transporter substrate-binding protein/permease -
MNU55_RS05190 (MNU55_05190) 1055232..1055954 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU55_RS05195 (MNU55_05195) 1056469..1056606 + 138 WP_064783702.1 hypothetical protein -
MNU55_RS05200 (MNU55_05200) 1056816..1057946 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU55_RS05205 (MNU55_05205) 1057943..1058413 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU55_RS05210 (MNU55_05210) 1058571..1059170 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU55_RS05215 (MNU55_05215) 1059194..1059373 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU55_RS05220 (MNU55_05220) 1059529..1059933 + 405 WP_001829818.1 hypothetical protein -
MNU55_RS05225 (MNU55_05225) 1060118..1061503 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU55_RS05230 (MNU55_05230) 1061864..1062688 - 825 WP_254104734.1 RluA family pseudouridine synthase -
MNU55_RS05235 (MNU55_05235) 1062847..1063980 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1056451..1056606 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237777 WP_002468490.1 NZ_CP093196:1059194-1059373 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237777 NZ_LR882938:546478-546876 [Planktothrix agardhii]
GTGAAATTATTGTTGGATACCCAATGCTGGTTATGGTGGTTTGCCCAACCTGAGCGATTAAATCAGGAAGTGATCGCACA
GATTGCCGATGAAAGTAATGAATTATGGTTTTCTGTTGCTAGTGTTTGGGAAATTGGGATTAAAGTTGCGATCAGAAAAT
TACCATTACCAGAGCCAATAGATACCTACATTTCTAGTCGTATGGTGCAGTTAGATATGCGATATTTGGAAATCACAGCA
CCTCATGCACTGCGATCATCTGCGTTACCATTACATCATCGAGATCCCTTTGATCGTATGTTGATTGCTCAGGCTCAGAT
TGAGGATATGACGCTGGTAAGTGCTGATTCAATGTTCAAGCAATACAGCGATATTTCTGTTCTTTGGGCTGCTAATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237777 WP_002456349.1 NZ_CP093196:1058571-1059170 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237777 NZ_LR882938:546233-546481 [Planktothrix agardhii]
ATTCAGATTGAAAACTTACCCAACGACTTCAAAAAAAATCTCTCTGAGTTATTGTCCCGTGTAGAACTTGGAGAAGAAAT
TATTATTTCCAATCAAGGGGTGGCGATCGCTAAGTTAATTCCGTTTCGTCCTTCATCCAATCGACGGGCGAGTTTAGGGC
AAGATCAAGGTAAATTTATCATACCAGATGACTTTAATGAACCGTTACCCCAAGAAATTTTGGCAGCATTTGAAGGAAAT
GAACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References