Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1024275..1025077 Replicon chromosome
Accession NZ_CP073878
Organism Staphylococcus epidermidis strain B1285228

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV29_RS05605 Protein ID WP_002468490.1
Coordinates 1024898..1025077 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV29_RS05600 Protein ID WP_002456349.1
Coordinates 1024275..1024874 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV29_RS05575 (KFV29_05575) 1019486..1020943 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV29_RS05580 (KFV29_05580) 1020936..1021658 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV29_RS05585 (KFV29_05585) 1022155..1022310 + 156 WP_001829854.1 hypothetical protein -
KFV29_RS05590 (KFV29_05590) 1022520..1023650 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV29_RS05595 (KFV29_05595) 1023647..1024117 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV29_RS05600 (KFV29_05600) 1024275..1024874 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV29_RS05605 (KFV29_05605) 1024898..1025077 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV29_RS05610 (KFV29_05610) 1025233..1025637 + 405 WP_001829818.1 hypothetical protein -
KFV29_RS05615 (KFV29_05615) 1025822..1027207 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV29_RS05620 (KFV29_05620) 1027568..1028391 - 824 Protein_1032 RluA family pseudouridine synthase -
KFV29_RS05625 (KFV29_05625) 1028550..1029683 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1022155..1022310 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200450 WP_002468490.1 NZ_CP073878:1024898-1025077 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200450 NZ_CP097881:c2373665-2373489 [Escherichia coli str. K-12 substr. MG1655]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200450 WP_002456349.1 NZ_CP073878:1024275-1024874 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200450 NZ_CP097881:c2373443-2373027 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References