Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1067172..1067974 Replicon chromosome
Accession NZ_CP069219
Organism Staphylococcus epidermidis strain Z0118SE0272

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag JQC90_RS05210 Protein ID WP_002468490.1
Coordinates 1067795..1067974 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag JQC90_RS05205 Protein ID WP_001829848.1
Coordinates 1067172..1067771 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC90_RS05180 1062383..1063840 + 1458 WP_203267777.1 ABC transporter substrate-binding protein/permease -
JQC90_RS05185 1063833..1064555 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
JQC90_RS05190 1065070..1065207 + 138 WP_064783702.1 hypothetical protein -
JQC90_RS05195 1065417..1066547 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
JQC90_RS05200 1066544..1067014 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
JQC90_RS05205 1067172..1067771 + 600 WP_001829848.1 hypothetical protein Antitoxin
JQC90_RS05210 1067795..1067974 + 180 WP_002468490.1 hypothetical protein Toxin
JQC90_RS05215 1068130..1068534 + 405 WP_001829818.1 hypothetical protein -
JQC90_RS05220 1068719..1070104 + 1386 WP_001829862.1 class II fumarate hydratase -
JQC90_RS05225 1070465..1071289 - 825 WP_001829804.1 RluA family pseudouridine synthase -
JQC90_RS05230 1071448..1072581 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1065052..1065207 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T190105 WP_002468490.1 NZ_CP069219:1067795-1067974 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T190105 NZ_CP091092:414273-414467 [Methanomicrobium antiquum]
ATGAAAGTCAGGGACGTCATAAAGTTATTAGAGAAAGAAGGCTGGCAGCTTGTTGCTGTCAGAGGAAGCCACCGGCAGTA
TAAAAATCCTGATGCTGCCGGGAGAATAACGGTTCCGGGCAGTATGAATGATTCGCTTGCGCCGGGAACATTGAACAGTA
TATTAAAGCAGGCAGGAATTAAGGAGAGGAGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22699.58 Da        Isoelectric Point: 4.9942

>AT190105 WP_001829848.1 NZ_CP069219:1067172-1067771 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHASVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT190105 NZ_CP091092:414467-414676 [Methanomicrobium antiquum]
ATGTTTAGGTTTCTGATTGTTGTTGAGAAGGCGGATTCCAACTATTCCGCATATTCCCCGGATATACCCGGATGTGTTGC
GACAGGAAAAACCCGTGAAGAGGCGGAGAAGAATATGCACGAGGCGATTGCATTTCATATCGAAGGTTTAAAGGAAGACC
GTCTTCCAATCCCCGAAGGTAAATCTTCTGCGTCCTGGGTTCTGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References