Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1178851..1179653 Replicon chromosome
Accession NZ_CP045648
Organism Staphylococcus epidermidis strain IRL01

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag GFV05_RS06040 Protein ID WP_002468490.1
Coordinates 1179474..1179653 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag GFV05_RS06035 Protein ID WP_002456349.1
Coordinates 1178851..1179450 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFV05_RS06010 1174062..1175519 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
GFV05_RS06015 1175512..1176234 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
GFV05_RS06020 1176749..1176886 + 138 WP_064783702.1 hypothetical protein -
GFV05_RS06025 1177096..1178226 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
GFV05_RS06030 1178223..1178693 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GFV05_RS06035 1178851..1179450 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
GFV05_RS06040 1179474..1179653 + 180 WP_002468490.1 hypothetical protein Toxin
GFV05_RS06045 1179809..1180213 + 405 WP_001829818.1 hypothetical protein -
GFV05_RS06050 1180398..1181783 + 1386 WP_001829862.1 class II fumarate hydratase -
GFV05_RS06055 1182144..1182968 - 825 Protein_1115 RluA family pseudouridine synthase -
GFV05_RS06060 1183127..1184260 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1176731..1176886 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T142255 WP_002468490.1 NZ_CP045648:1179474-1179653 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T142255 NZ_CP060509:171373-171678 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT142255 WP_002456349.1 NZ_CP045648:1178851-1179450 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT142255 NZ_CP060509:171153-171371 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References