Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1272918..1273720 Replicon chromosome
Accession NZ_CP073865
Organism Staphylococcus epidermidis strain B1276912

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV35_RS06565 Protein ID WP_002468490.1
Coordinates 1273541..1273720 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV35_RS06560 Protein ID WP_002456349.1
Coordinates 1272918..1273517 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV35_RS06535 (KFV35_06575) 1268129..1269586 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV35_RS06540 (KFV35_06580) 1269579..1270301 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV35_RS06545 (KFV35_06585) 1270798..1270953 + 156 WP_001829854.1 hypothetical protein -
KFV35_RS06550 (KFV35_06590) 1271163..1272293 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV35_RS06555 (KFV35_06595) 1272290..1272760 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV35_RS06560 (KFV35_06600) 1272918..1273517 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV35_RS06565 (KFV35_06605) 1273541..1273720 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV35_RS06570 (KFV35_06610) 1273876..1274280 + 405 WP_001829818.1 hypothetical protein -
KFV35_RS06575 (KFV35_06615) 1274465..1275850 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV35_RS06580 (KFV35_06620) 1276211..1277034 - 824 Protein_1259 RluA family pseudouridine synthase -
KFV35_RS06585 (KFV35_06625) 1277193..1278326 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1270798..1270953 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200430 WP_002468490.1 NZ_CP073865:1273541-1273720 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200430 NZ_CP097870:3614288-3614701 [Thauera sp. GDN1]
TTGAGCTACCTGATCGACACCAACGTGTTGTCCGAACTGCGGCGCAAGTCTCCAGACCCCGGCGTGGTCGCCTGGTTTTC
GCAGCGGCCGCCCACCACCCTGCATCTCTCTGTGCTGACGCTCGGCGAGATTCGCAAGGGCATTGAAGGCGTGGGTGACG
AAGTTCGAAAGCAGACGCTGATCGATTGGCTCGAAACGGATCTCCCCACCTTCTTCACCGGGCGCATCCTCGACGTCAAT
GGCGCAGTGGCCGATCGCTGGGGGCGTCTGGTCGCTGCAGCCGGACGACCGCTGCCCACGATCGACAGCCTGCTCGCAGC
GACCGCCCTGGAACACGATCTGGTACTGGTGACACGCAACACCAAGGATTTCGCCGGTCTGCCCGTCGAGGTCTTCAACC
CCTGGACGAGCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200430 WP_002456349.1 NZ_CP073865:1272918-1273517 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200430 NZ_CP097870:3614058-3614291 [Thauera sp. GDN1]
ATGCAGGAAGCGAAGGCGCGCATGTCGGAGTTGGTCAAGCGCGCCCAGACCCAGCCCCAGGACATCACCCTGCACGGCAA
GTCGGTCGCAGTGGTGATCTCGCGCGAAACTTTTGATCGGTTGTCACAGGCGCAGGACTCGCTGGTGGACTTCATGCGAC
GCTCACCCTTGTTCGGAACAGACGACATAGCCCTCGAACGCGAGCAGAGCCTGACGCGCGAGGTCTTGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References