Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1070670..1071472 Replicon chromosome
Accession NZ_CP097514
Organism Staphylococcus epidermidis strain C034

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag M8Z30_RS05215 Protein ID WP_002468490.1
Coordinates 1071293..1071472 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag M8Z30_RS05210 Protein ID WP_002456349.1
Coordinates 1070670..1071269 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z30_RS05185 (M8Z30_05185) 1065881..1067338 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
M8Z30_RS05190 (M8Z30_05190) 1067331..1068053 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
M8Z30_RS05195 (M8Z30_05195) 1068568..1068705 + 138 WP_064783702.1 hypothetical protein -
M8Z30_RS05200 (M8Z30_05200) 1068915..1070045 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
M8Z30_RS05205 (M8Z30_05205) 1070042..1070512 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8Z30_RS05210 (M8Z30_05210) 1070670..1071269 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
M8Z30_RS05215 (M8Z30_05215) 1071293..1071472 + 180 WP_002468490.1 SAS053 family protein Toxin
M8Z30_RS05220 (M8Z30_05220) 1071628..1072032 + 405 WP_001829818.1 hypothetical protein -
M8Z30_RS05225 (M8Z30_05225) 1072217..1073602 + 1386 WP_001829862.1 class II fumarate hydratase -
M8Z30_RS05230 (M8Z30_05230) 1073963..1074787 - 825 WP_001829804.1 RluA family pseudouridine synthase -
M8Z30_RS05235 (M8Z30_05235) 1074946..1076079 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1068550..1068705 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T245514 WP_002468490.1 NZ_CP097514:1071293-1071472 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT245514 WP_002456349.1 NZ_CP097514:1070670-1071269 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References