Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1058769..1059571 Replicon chromosome
Accession NZ_CP093205
Organism Staphylococcus epidermidis strain TSM-36

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU43_RS05040 Protein ID WP_002468490.1
Coordinates 1059392..1059571 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU43_RS05035 Protein ID WP_002456349.1
Coordinates 1058769..1059368 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU43_RS05010 (MNU43_05005) 1053980..1055437 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MNU43_RS05015 (MNU43_05010) 1055430..1056152 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU43_RS05020 (MNU43_05015) 1056649..1056804 + 156 WP_001829854.1 hypothetical protein -
MNU43_RS05025 (MNU43_05020) 1057014..1058144 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU43_RS05030 (MNU43_05025) 1058141..1058611 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU43_RS05035 (MNU43_05030) 1058769..1059368 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU43_RS05040 (MNU43_05035) 1059392..1059571 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU43_RS05045 (MNU43_05040) 1059727..1060131 + 405 WP_001829818.1 hypothetical protein -
MNU43_RS05050 (MNU43_05045) 1060316..1061701 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU43_RS05055 (MNU43_05050) 1062062..1062886 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MNU43_RS05060 (MNU43_05055) 1063045..1064178 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1056649..1056804 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237792 WP_002468490.1 NZ_CP093205:1059392-1059571 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237792 NZ_LR882950:c4509226-4508972 [Planktothrix agardhii]
ATGAAAGTAGTAACGTTTAGCGAAGCGAAAAGCCAATTAAAAACGGTGTTAGATCGGGTAGTTGAAGATGCTGACTACAC
CATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCTTGATTATTTTAATGGTTTACTGGAAACGGTTCATT
TATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTGCCCAATATAGGCAGGGGAAAGCTCTTGAACATCAG
TTGATAGATGAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237792 WP_002456349.1 NZ_CP093205:1058769-1059368 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237792 NZ_LR882950:c4508979-4508716 [Planktothrix agardhii]
ATGAGTAACCGCATATTAGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAGACTCT
CAAAAAAATTAATAAACTGCTAGATGCAATCAAAAAACGTCCCTTTGAAGGAATTGGTAAACCTGAACCTTTGAAAGAAA
ATTTATCTGGTTTTTGGTCACGTCGTATTGATGATACTAATCGTCTAGTTTACGTTGTCGATGATCTCTATATCACGATC
ATTTCTTGTCGTTATCATTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References