192274

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1439249..1440051 Replicon chromosome
Accession NZ_CP069951
Organism Staphylococcus epidermidis strain FDAARGOS_1363

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag I6K93_RS06870 Protein ID WP_002468490.1
Coordinates 1439249..1439428 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag I6K93_RS06875 Protein ID WP_002456349.1
Coordinates 1439452..1440051 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K93_RS06850 1434642..1435775 - 1134 WP_049319185.1 GAF domain-containing sensor histidine kinase -
I6K93_RS06855 1435934..1436758 + 825 WP_001829804.1 RluA family pseudouridine synthase -
I6K93_RS06860 1437119..1438504 - 1386 WP_032603319.1 class II fumarate hydratase -
I6K93_RS06865 1438689..1439093 - 405 WP_001829818.1 hypothetical protein -
I6K93_RS06870 1439249..1439428 - 180 WP_002468490.1 hypothetical protein Toxin
I6K93_RS06875 1439452..1440051 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
I6K93_RS06880 1440209..1440679 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I6K93_RS06885 1440676..1441806 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
I6K93_RS06890 1442016..1442171 - 156 WP_001829854.1 hypothetical protein -
I6K93_RS06895 1442668..1443390 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
I6K93_RS06900 1443383..1444840 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1442016..1442171 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T192274 WP_002468490.1 NZ_CP069951:c1439428-1439249 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T192274 NZ_CP092283:c1914392-1914126 [Marinobacter sp. M4C]
ATGATTAGATCATTCCGTCACAAAGGTCTGAAACGGTTCTACTCGTCTGGCATACAGTCTGATCACGCCAAGAAGCTGCG
CATGCAGCTCGCTGCTCTGAATACCGCCATTTCGGTAGAAGACATAGACATCCCTGGTTTTCGGCTTCACTCATTGAAGG
GAACAGACAAAGGGCGGTGGTCGATTTGGGTTAACGGAAATTGGCGCATGACGTTCGAATTTCAGGACAGCAACGCCTAC
ATTCTTGATTATGAGGATTACCACTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT192274 WP_002456349.1 NZ_CP069951:c1440051-1439452 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT192274 NZ_CP092283:c1914126-1913833 [Marinobacter sp. M4C]
ATGACTATGCATAACCCGCCACATCCTGGTGAGTTCATTCGGGAGGTGTATCTGGAGCCTTTCGGCATCAGTTCCCGTCA
GCTTGCTTCCAGTTTGGGCGTTTCCCCTTCTACGTTGTCTCGCTTGCTCAAAGGGGATAGTGGTATCAGCCCGGAGATGT
CTTTGCGGCTATCTAAGGTTCTCGGGCGTACTCCTGAGAGCTGGTTGGCTATGCAAGATATGTATGATCTATGGGTAGCC
CGTAGCACGGTCAATCTGGATGGTATTCATCCCTTGGACTTCGAAGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References