Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1020370..1021172 Replicon chromosome
Accession NZ_LR735434
Organism Staphylococcus epidermidis strain none isolate Se_BPH0736

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag GOZ11_RS05115 Protein ID WP_002468490.1
Coordinates 1020993..1021172 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag GOZ11_RS05110 Protein ID WP_155974624.1
Coordinates 1020370..1020969 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ11_RS05085 1015581..1017038 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
GOZ11_RS05090 1017031..1017753 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
GOZ11_RS05095 1018268..1018405 + 138 WP_064783702.1 hypothetical protein -
GOZ11_RS05100 1018615..1019745 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
GOZ11_RS05105 1019742..1020212 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GOZ11_RS05110 1020370..1020969 + 600 WP_155974624.1 glucosamine-6-phosphate isomerase Antitoxin
GOZ11_RS05115 1020993..1021172 + 180 WP_002468490.1 hypothetical protein Toxin
GOZ11_RS05120 1021328..1021732 + 405 WP_001829818.1 hypothetical protein -
GOZ11_RS05125 1021917..1023302 + 1386 WP_001829862.1 class II fumarate hydratase -
GOZ11_RS05130 1023663..1024487 - 825 WP_001829804.1 RluA family pseudouridine synthase -
GOZ11_RS05135 1024646..1025779 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1018250..1018405 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T288884 WP_002468490.1 NZ_LR735434:1020993-1021172 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22708.64 Da        Isoelectric Point: 5.1497

>AT288884 WP_155974624.1 NZ_LR735434:1020370-1020969 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISNKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References