Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1037659..1038461 Replicon chromosome
Accession NZ_LR735440
Organism Staphylococcus epidermidis strain none isolate Se_BPH0711

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag GOZ26_RS05245 Protein ID WP_002468490.1
Coordinates 1038282..1038461 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag GOZ26_RS05240 Protein ID WP_001829848.1
Coordinates 1037659..1038258 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ26_RS05215 1032870..1034327 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
GOZ26_RS05220 1034320..1035042 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
GOZ26_RS05225 1035557..1035694 + 138 WP_064783702.1 hypothetical protein -
GOZ26_RS05230 1035904..1037034 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
GOZ26_RS05235 1037031..1037501 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
GOZ26_RS05240 1037659..1038258 + 600 WP_001829848.1 hypothetical protein Antitoxin
GOZ26_RS05245 1038282..1038461 + 180 WP_002468490.1 hypothetical protein Toxin
GOZ26_RS05250 1038617..1039021 + 405 WP_001829818.1 hypothetical protein -
GOZ26_RS05255 1039206..1040591 + 1386 WP_001829862.1 class II fumarate hydratase -
GOZ26_RS05260 1040952..1041776 - 825 WP_001829804.1 RluA family pseudouridine synthase -
GOZ26_RS05265 1041935..1043068 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1035539..1035694 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T288892 WP_002468490.1 NZ_LR735440:1038282-1038461 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22699.58 Da        Isoelectric Point: 4.9942

>AT288892 WP_001829848.1 NZ_LR735440:1037659-1038258 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHASVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References