285113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1563246..1564048 Replicon chromosome
Accession NZ_HG813242
Organism Staphylococcus epidermidis PM221

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag SEB_RS07300 Protein ID WP_002468490.1
Coordinates 1563246..1563425 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag SEB_RS07305 Protein ID WP_038399510.1
Coordinates 1563449..1564048 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEB_RS07280 1558639..1559772 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
SEB_RS07285 1559931..1560755 + 825 WP_001829804.1 RluA family pseudouridine synthase -
SEB_RS07290 1561116..1562501 - 1386 WP_001829862.1 class II fumarate hydratase -
SEB_RS07295 1562686..1563090 - 405 WP_001829818.1 hypothetical protein -
SEB_RS07300 1563246..1563425 - 180 WP_002468490.1 hypothetical protein Toxin
SEB_RS07305 1563449..1564048 - 600 WP_038399510.1 glucosamine-6-phosphate isomerase Antitoxin
SEB_RS07310 1564206..1564676 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SEB_RS07315 1564673..1565803 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
SEB_RS13320 1566013..1566168 - 156 WP_001829854.1 hypothetical protein -
SEB_RS07325 1566665..1567387 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
SEB_RS07330 1567380..1568837 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1566013..1566168 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T285113 WP_002468490.1 NZ_HG813242:c1563425-1563246 [Staphylococcus epidermidis PM221]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22723.69 Da        Isoelectric Point: 5.1598

>AT285113 WP_038399510.1 NZ_HG813242:c1564048-1563449 [Staphylococcus epidermidis PM221]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVEKHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References