Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 926898..927700 | Replicon | chromosome |
Accession | NZ_CP093222 | ||
Organism | Staphylococcus epidermidis strain CICARIA |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | Q5HN83 |
Locus tag | MMZ11_RS04585 | Protein ID | WP_002468490.1 |
Coordinates | 927521..927700 (+) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | Q5HN82 |
Locus tag | MMZ11_RS04580 | Protein ID | WP_002456349.1 |
Coordinates | 926898..927497 (+) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MMZ11_RS04555 (MMZ11_04555) | 922110..923567 | + | 1458 | WP_011082742.1 | ABC transporter substrate-binding protein/permease | - |
MMZ11_RS04560 (MMZ11_04560) | 923560..924282 | + | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
MMZ11_RS04565 (MMZ11_04565) | 924779..924934 | + | 156 | WP_001829854.1 | hypothetical protein | - |
MMZ11_RS04570 (MMZ11_04570) | 925143..926273 | + | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
MMZ11_RS04575 (MMZ11_04575) | 926270..926740 | + | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
MMZ11_RS04580 (MMZ11_04580) | 926898..927497 | + | 600 | WP_002456349.1 | glucosamine-6-phosphate isomerase | Antitoxin |
MMZ11_RS04585 (MMZ11_04585) | 927521..927700 | + | 180 | WP_002468490.1 | SAS053 family protein | Toxin |
MMZ11_RS04590 (MMZ11_04590) | 927856..928260 | + | 405 | WP_001829818.1 | hypothetical protein | - |
MMZ11_RS04595 (MMZ11_04595) | 928445..929830 | + | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
MMZ11_RS04600 (MMZ11_04600) | 930191..931015 | - | 825 | WP_001829804.1 | RluA family pseudouridine synthase | - |
MMZ11_RS04605 (MMZ11_04605) | 931174..932307 | + | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 924779..924934 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T237848 WP_002468490.1 NZ_CP093222:927521-927700 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
>T237848 NZ_LR882978:2846990-2847097 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCGCGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCGCGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22709.62 Da Isoelectric Point: 4.9942
>AT237848 WP_002456349.1 NZ_CP093222:926898-927497 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
>AT237848 NZ_LR882978:c2846943-2846877 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HY44 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E9LUD0 |