Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 926898..927700 Replicon chromosome
Accession NZ_CP093222
Organism Staphylococcus epidermidis strain CICARIA

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MMZ11_RS04585 Protein ID WP_002468490.1
Coordinates 927521..927700 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MMZ11_RS04580 Protein ID WP_002456349.1
Coordinates 926898..927497 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ11_RS04555 (MMZ11_04555) 922110..923567 + 1458 WP_011082742.1 ABC transporter substrate-binding protein/permease -
MMZ11_RS04560 (MMZ11_04560) 923560..924282 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MMZ11_RS04565 (MMZ11_04565) 924779..924934 + 156 WP_001829854.1 hypothetical protein -
MMZ11_RS04570 (MMZ11_04570) 925143..926273 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MMZ11_RS04575 (MMZ11_04575) 926270..926740 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MMZ11_RS04580 (MMZ11_04580) 926898..927497 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MMZ11_RS04585 (MMZ11_04585) 927521..927700 + 180 WP_002468490.1 SAS053 family protein Toxin
MMZ11_RS04590 (MMZ11_04590) 927856..928260 + 405 WP_001829818.1 hypothetical protein -
MMZ11_RS04595 (MMZ11_04595) 928445..929830 + 1386 WP_001829862.1 class II fumarate hydratase -
MMZ11_RS04600 (MMZ11_04600) 930191..931015 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MMZ11_RS04605 (MMZ11_04605) 931174..932307 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 924779..924934 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237848 WP_002468490.1 NZ_CP093222:927521-927700 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237848 NZ_LR882978:2846990-2847097 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCGCGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237848 WP_002456349.1 NZ_CP093222:926898-927497 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237848 NZ_LR882978:c2846943-2846877 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References