232270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1476652..1477454 Replicon chromosome
Accession NZ_CP090985
Organism Staphylococcus epidermidis strain 50D

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB226_RS07040 Protein ID WP_002468490.1
Coordinates 1476652..1476831 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A8B5RW65
Locus tag KB226_RS07045 Protein ID WP_002470400.1
Coordinates 1476855..1477454 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB226_RS07020 (KB226_07020) 1472045..1473178 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KB226_RS07025 (KB226_07025) 1473337..1474161 + 825 WP_001829804.1 RluA family pseudouridine synthase -
KB226_RS07030 (KB226_07030) 1474522..1475907 - 1386 WP_001829862.1 class II fumarate hydratase -
KB226_RS07035 (KB226_07035) 1476092..1476496 - 405 WP_001829818.1 hypothetical protein -
KB226_RS07040 (KB226_07040) 1476652..1476831 - 180 WP_002468490.1 SAS053 family protein Toxin
KB226_RS07045 (KB226_07045) 1476855..1477454 - 600 WP_002470400.1 hypothetical protein Antitoxin
KB226_RS07050 (KB226_07050) 1477612..1478082 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB226_RS07055 (KB226_07055) 1478079..1479209 - 1131 WP_002470398.1 tRNA epoxyqueuosine(34) reductase QueG -
KB226_RS07060 (KB226_07060) 1479419..1479574 - 156 WP_001829854.1 hypothetical protein -
KB226_RS07065 (KB226_07065) 1480071..1480793 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB226_RS07070 (KB226_07070) 1480786..1482242 - 1457 Protein_1371 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1479419..1479574 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232270 WP_002468490.1 NZ_CP090985:c1476831-1476652 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232270 NZ_CP127275:1534660-1535481 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22699.58 Da        Isoelectric Point: 4.9942

>AT232270 WP_002470400.1 NZ_CP090985:c1477454-1476855 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLSEDVKEYFTARFA

Download         Length: 600 bp

>AT232270 NZ_CP127275:1535474-1535710 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RW65

References