Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1755384..1756186 Replicon chromosome
Accession NZ_CP073898
Organism Staphylococcus epidermidis strain V1939586

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV32_RS08080 Protein ID WP_002468490.1
Coordinates 1755384..1755563 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV32_RS08085 Protein ID WP_002456349.1
Coordinates 1755587..1756186 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV32_RS08060 (KFV32_08070) 1750778..1751911 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV32_RS08065 (KFV32_08075) 1752070..1752893 + 824 Protein_1604 RluA family pseudouridine synthase -
KFV32_RS08070 (KFV32_08080) 1753254..1754639 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV32_RS08075 (KFV32_08085) 1754824..1755228 - 405 WP_001829818.1 hypothetical protein -
KFV32_RS08080 (KFV32_08090) 1755384..1755563 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV32_RS08085 (KFV32_08095) 1755587..1756186 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV32_RS08090 (KFV32_08100) 1756344..1756814 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV32_RS08095 (KFV32_08105) 1756811..1757941 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV32_RS08100 (KFV32_08110) 1758151..1758306 - 156 WP_001829854.1 hypothetical protein -
KFV32_RS08105 (KFV32_08115) 1758803..1759525 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV32_RS08110 (KFV32_08120) 1759518..1760975 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1758151..1758306 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200481 WP_002468490.1 NZ_CP073898:c1755563-1755384 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200481 NZ_CP097882:3653150-3653491 [Escherichia coli str. K-12 substr. MG1655]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200481 WP_002456349.1 NZ_CP073898:c1756186-1755587 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200481 NZ_CP097882:3652812-3653129 [Escherichia coli str. K-12 substr. MG1655]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References