Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1368147..1368949 Replicon chromosome
Accession NZ_CP068136
Organism Staphylococcus epidermidis strain FDAARGOS_1083

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag I6I40_RS06590 Protein ID WP_002468490.1
Coordinates 1368770..1368949 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag I6I40_RS06585 Protein ID WP_002456349.1
Coordinates 1368147..1368746 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I40_RS06560 1363358..1364815 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
I6I40_RS06565 1364808..1365530 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
I6I40_RS06570 1366045..1366182 + 138 WP_064783702.1 hypothetical protein -
I6I40_RS06575 1366392..1367522 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
I6I40_RS06580 1367519..1367989 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I6I40_RS06585 1368147..1368746 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
I6I40_RS06590 1368770..1368949 + 180 WP_002468490.1 hypothetical protein Toxin
I6I40_RS06595 1369105..1369509 + 405 WP_001829818.1 hypothetical protein -
I6I40_RS06600 1369694..1371079 + 1386 WP_001829862.1 class II fumarate hydratase -
I6I40_RS06605 1371440..1372264 - 825 WP_001829804.1 RluA family pseudouridine synthase -
I6I40_RS06610 1372423..1373556 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1366027..1366182 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T186658 WP_002468490.1 NZ_CP068136:1368770-1368949 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T186658 NZ_CP089611:c2205142-2204846 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT186658 WP_002456349.1 NZ_CP068136:1368147-1368746 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT186658 NZ_CP089611:c2205390-2205139 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References