Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 963101..963903 Replicon chromosome
Accession NZ_CP091006
Organism Staphylococcus epidermidis strain R10C

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB224_RS04655 Protein ID WP_002468490.1
Coordinates 963724..963903 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A8B5RW65
Locus tag KB224_RS04650 Protein ID WP_002470400.1
Coordinates 963101..963700 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB224_RS04625 (KB224_04625) 958314..959770 + 1457 Protein_878 ABC transporter substrate-binding protein/permease -
KB224_RS04630 (KB224_04630) 959763..960485 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB224_RS04635 (KB224_04635) 960999..961136 + 138 WP_064783702.1 hypothetical protein -
KB224_RS04640 (KB224_04640) 961346..962476 + 1131 WP_002470398.1 tRNA epoxyqueuosine(34) reductase QueG -
KB224_RS04645 (KB224_04645) 962473..962943 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB224_RS04650 (KB224_04650) 963101..963700 + 600 WP_002470400.1 hypothetical protein Antitoxin
KB224_RS04655 (KB224_04655) 963724..963903 + 180 WP_002468490.1 SAS053 family protein Toxin
KB224_RS04660 (KB224_04660) 964059..964463 + 405 WP_001829818.1 hypothetical protein -
KB224_RS04665 (KB224_04665) 964648..966033 + 1386 WP_001829862.1 class II fumarate hydratase -
KB224_RS04670 (KB224_04670) 966394..967218 - 825 WP_001829804.1 RluA family pseudouridine synthase -
KB224_RS04675 (KB224_04675) 967377..968510 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 960981..961136 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232291 WP_002468490.1 NZ_CP091006:963724-963903 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232291 NZ_CP127275:2909453-2909893 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22699.58 Da        Isoelectric Point: 4.9942

>AT232291 WP_002470400.1 NZ_CP091006:963101-963700 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLSEDVKEYFTARFA

Download         Length: 600 bp

>AT232291 NZ_CP127275:2909179-2909466 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RW65

References