Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1690207..1691009 Replicon chromosome
Accession NZ_CP073827
Organism Staphylococcus epidermidis strain B1208538

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV36_RS07775 Protein ID WP_002468490.1
Coordinates 1690207..1690386 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV36_RS07780 Protein ID WP_002456349.1
Coordinates 1690410..1691009 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV36_RS07755 (KFV36_07765) 1685601..1686734 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
KFV36_RS07760 (KFV36_07770) 1686893..1687716 + 824 Protein_1546 RluA family pseudouridine synthase -
KFV36_RS07765 (KFV36_07775) 1688077..1689462 - 1386 WP_001829862.1 class II fumarate hydratase -
KFV36_RS07770 (KFV36_07780) 1689647..1690051 - 405 WP_001829818.1 hypothetical protein -
KFV36_RS07775 (KFV36_07785) 1690207..1690386 - 180 WP_002468490.1 SAS053 family protein Toxin
KFV36_RS07780 (KFV36_07790) 1690410..1691009 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV36_RS07785 (KFV36_07795) 1691167..1691637 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV36_RS07790 (KFV36_07800) 1691634..1692764 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV36_RS07795 (KFV36_07805) 1692974..1693111 - 138 WP_064783702.1 hypothetical protein -
KFV36_RS07800 (KFV36_07810) 1693626..1694348 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV36_RS07805 (KFV36_07815) 1694341..1695798 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1692974..1693129 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200351 WP_002468490.1 NZ_CP073827:c1690386-1690207 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200351 NZ_CP097834:c1342951-1342796 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200351 WP_002456349.1 NZ_CP073827:c1691009-1690410 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200351 NZ_CP097834:1342963-1343021 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References