Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 1690207..1691009 | Replicon | chromosome |
Accession | NZ_CP073827 | ||
Organism | Staphylococcus epidermidis strain B1208538 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | Q5HN83 |
Locus tag | KFV36_RS07775 | Protein ID | WP_002468490.1 |
Coordinates | 1690207..1690386 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | Q5HN82 |
Locus tag | KFV36_RS07780 | Protein ID | WP_002456349.1 |
Coordinates | 1690410..1691009 (-) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFV36_RS07755 (KFV36_07765) | 1685601..1686734 | - | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
KFV36_RS07760 (KFV36_07770) | 1686893..1687716 | + | 824 | Protein_1546 | RluA family pseudouridine synthase | - |
KFV36_RS07765 (KFV36_07775) | 1688077..1689462 | - | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
KFV36_RS07770 (KFV36_07780) | 1689647..1690051 | - | 405 | WP_001829818.1 | hypothetical protein | - |
KFV36_RS07775 (KFV36_07785) | 1690207..1690386 | - | 180 | WP_002468490.1 | SAS053 family protein | Toxin |
KFV36_RS07780 (KFV36_07790) | 1690410..1691009 | - | 600 | WP_002456349.1 | glucosamine-6-phosphate isomerase | Antitoxin |
KFV36_RS07785 (KFV36_07795) | 1691167..1691637 | - | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
KFV36_RS07790 (KFV36_07800) | 1691634..1692764 | - | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
KFV36_RS07795 (KFV36_07805) | 1692974..1693111 | - | 138 | WP_064783702.1 | hypothetical protein | - |
KFV36_RS07800 (KFV36_07810) | 1693626..1694348 | - | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
KFV36_RS07805 (KFV36_07815) | 1694341..1695798 | - | 1458 | WP_002440300.1 | ABC transporter substrate-binding protein/permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 1692974..1693129 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T200351 WP_002468490.1 NZ_CP073827:c1690386-1690207 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
>T200351 NZ_CP097834:c1342951-1342796 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22709.62 Da Isoelectric Point: 4.9942
>AT200351 WP_002456349.1 NZ_CP073827:c1691009-1690410 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
>AT200351 NZ_CP097834:1342963-1343021 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HY44 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E9LUD0 |