Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1028992..1029794 Replicon chromosome
Accession NZ_CP073852
Organism Staphylococcus epidermidis strain B1266915

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV26_RS05490 Protein ID WP_002468490.1
Coordinates 1029615..1029794 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV26_RS05485 Protein ID WP_002456349.1
Coordinates 1028992..1029591 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV26_RS05460 (KFV26_05460) 1024203..1025660 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV26_RS05465 (KFV26_05465) 1025653..1026375 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV26_RS05470 (KFV26_05470) 1026890..1027027 + 138 WP_064783702.1 hypothetical protein -
KFV26_RS05475 (KFV26_05475) 1027237..1028367 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV26_RS05480 (KFV26_05480) 1028364..1028834 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV26_RS05485 (KFV26_05485) 1028992..1029591 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV26_RS05490 (KFV26_05490) 1029615..1029794 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV26_RS05495 (KFV26_05495) 1029950..1030354 + 405 WP_001829818.1 hypothetical protein -
KFV26_RS05500 (KFV26_05500) 1030539..1031924 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV26_RS05505 (KFV26_05505) 1032285..1033108 - 824 Protein_1042 RluA family pseudouridine synthase -
KFV26_RS05510 (KFV26_05510) 1033267..1034400 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1026872..1027027 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200400 WP_002468490.1 NZ_CP073852:1029615-1029794 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200400 NZ_CP097840:4356568-4356786 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200400 WP_002456349.1 NZ_CP073852:1028992-1029591 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200400 NZ_CP097840:4356168-4356542 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References