Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 999233..1000035 Replicon chromosome
Accession NZ_CP093208
Organism Staphylococcus epidermidis strain TSM-47

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU33_RS04865 Protein ID WP_002468490.1
Coordinates 999856..1000035 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MNU33_RS04860 Protein ID WP_001829848.1
Coordinates 999233..999832 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU33_RS04835 (MNU33_04830) 994444..995901 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MNU33_RS04840 (MNU33_04835) 995894..996616 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU33_RS04845 (MNU33_04840) 997131..997268 + 138 WP_064783702.1 hypothetical protein -
MNU33_RS04850 (MNU33_04845) 997478..998608 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU33_RS04855 (MNU33_04850) 998605..999075 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU33_RS04860 (MNU33_04855) 999233..999832 + 600 WP_001829848.1 hypothetical protein Antitoxin
MNU33_RS04865 (MNU33_04860) 999856..1000035 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU33_RS04870 (MNU33_04865) 1000191..1000595 + 405 WP_001829818.1 hypothetical protein -
MNU33_RS04875 (MNU33_04870) 1000780..1002165 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU33_RS04880 (MNU33_04875) 1002526..1003350 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MNU33_RS04885 (MNU33_04880) 1003509..1004642 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 997113..997268 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237797 WP_002468490.1 NZ_CP093208:999856-1000035 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237797 NZ_LR882952:c2390627-2390439 [Planktothrix agardhii]
ATGAAAGTAAAAGATATTATTAAACGATTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATT
TAAACATCCTGTAAAATCTGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTA
TTATTAAACAAGCTCAAATTAATCTTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22699.58 Da        Isoelectric Point: 4.9942

>AT237797 WP_001829848.1 NZ_CP093208:999233-999832 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHASVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237797 NZ_LR882952:c2390418-2390209 [Planktothrix agardhii]
ATGAAACGTTATGCAATTGTTATTGAAAAAGCGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACAGGTTACACCATAGAAGAAATTGAAACAGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GTTTACCGATTCCTGAACCTGTGGCTATATCCGAATATGTTGAAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References