Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 999233..1000035 | Replicon | chromosome |
Accession | NZ_CP093208 | ||
Organism | Staphylococcus epidermidis strain TSM-47 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | Q5HN83 |
Locus tag | MNU33_RS04865 | Protein ID | WP_002468490.1 |
Coordinates | 999856..1000035 (+) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | - |
Locus tag | MNU33_RS04860 | Protein ID | WP_001829848.1 |
Coordinates | 999233..999832 (+) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MNU33_RS04835 (MNU33_04830) | 994444..995901 | + | 1458 | WP_002440300.1 | ABC transporter substrate-binding protein/permease | - |
MNU33_RS04840 (MNU33_04835) | 995894..996616 | + | 723 | WP_001829838.1 | amino acid ABC transporter ATP-binding protein | - |
MNU33_RS04845 (MNU33_04840) | 997131..997268 | + | 138 | WP_064783702.1 | hypothetical protein | - |
MNU33_RS04850 (MNU33_04845) | 997478..998608 | + | 1131 | WP_001829814.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
MNU33_RS04855 (MNU33_04850) | 998605..999075 | + | 471 | WP_001829836.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
MNU33_RS04860 (MNU33_04855) | 999233..999832 | + | 600 | WP_001829848.1 | hypothetical protein | Antitoxin |
MNU33_RS04865 (MNU33_04860) | 999856..1000035 | + | 180 | WP_002468490.1 | SAS053 family protein | Toxin |
MNU33_RS04870 (MNU33_04865) | 1000191..1000595 | + | 405 | WP_001829818.1 | hypothetical protein | - |
MNU33_RS04875 (MNU33_04870) | 1000780..1002165 | + | 1386 | WP_001829862.1 | class II fumarate hydratase | - |
MNU33_RS04880 (MNU33_04875) | 1002526..1003350 | - | 825 | WP_001829804.1 | RluA family pseudouridine synthase | - |
MNU33_RS04885 (MNU33_04880) | 1003509..1004642 | + | 1134 | WP_001829819.1 | GAF domain-containing sensor histidine kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 997113..997268 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6963.56 Da Isoelectric Point: 4.3016
>T237797 WP_002468490.1 NZ_CP093208:999856-1000035 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ
Download Length: 180 bp
>T237797 NZ_LR882952:c2390627-2390439 [Planktothrix agardhii]
ATGAAAGTAAAAGATATTATTAAACGATTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATT
TAAACATCCTGTAAAATCTGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTA
TTATTAAACAAGCTCAAATTAATCTTTAA
ATGAAAGTAAAAGATATTATTAAACGATTAGAAGAAGAAGGTTGGTATTTAGCAAGGACTAGAGGAAGCCACCGACAATT
TAAACATCCTGTAAAATCTGGTCTGGTCACGGTTCCTGGTAAACTATCAGATGATTTAGCACCAGGAACATTAAACAGTA
TTATTAAACAAGCTCAAATTAATCTTTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22699.58 Da Isoelectric Point: 4.9942
>AT237797 WP_001829848.1 NZ_CP093208:999233-999832 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHASVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHASVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA
Download Length: 600 bp
>AT237797 NZ_LR882952:c2390418-2390209 [Planktothrix agardhii]
ATGAAACGTTATGCAATTGTTATTGAAAAAGCGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACAGGTTACACCATAGAAGAAATTGAAACAGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GTTTACCGATTCCTGAACCTGTGGCTATATCCGAATATGTTGAAGTTTAA
ATGAAACGTTATGCAATTGTTATTGAAAAAGCGGCTATGAACTATTCTGCTTATGTTCCAGATTTGCCCGGATGTGTGGC
GACAGGTTACACCATAGAAGAAATTGAAACAGAAATTAGAGAAGCGATTATTTTTCATCTGGAAGGGTTAGAAATCGAAG
GTTTACCGATTCCTGAACCTGTGGCTATATCCGAATATGTTGAAGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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