237783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1069993..1070795 Replicon chromosome
Accession NZ_CP093198
Organism Staphylococcus epidermidis strain TSM-18

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU36_RS05340 Protein ID WP_002468490.1
Coordinates 1070616..1070795 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU36_RS05335 Protein ID WP_002456349.1
Coordinates 1069993..1070592 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU36_RS05310 (MNU36_05310) 1065204..1066661 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MNU36_RS05315 (MNU36_05315) 1066654..1067376 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU36_RS05320 (MNU36_05320) 1067873..1068028 + 156 WP_001829854.1 hypothetical protein -
MNU36_RS05325 (MNU36_05325) 1068238..1069368 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU36_RS05330 (MNU36_05330) 1069365..1069835 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU36_RS05335 (MNU36_05335) 1069993..1070592 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU36_RS05340 (MNU36_05340) 1070616..1070795 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU36_RS05345 (MNU36_05345) 1070951..1071355 + 405 WP_001829818.1 hypothetical protein -
MNU36_RS05350 (MNU36_05350) 1071540..1072925 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU36_RS05355 (MNU36_05355) 1073286..1074110 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MNU36_RS05360 (MNU36_05360) 1074269..1075402 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1067873..1068028 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237783 WP_002468490.1 NZ_CP093198:1070616-1070795 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237783 NZ_LR882944:259214-259612 [Planktothrix agardhii]
GTGAAATTATTGTTGGATACCCAATGCTGGTTGTGGTGGTTTGCCCAACCTGAGCGATTAAATCAAGAAGTGATCGCACA
GATTGCCGATGAAAGTAATGAATTATGGTTTTCTGTTGCTAGTGTTTGGGAAATTGGGATCAAAGTTGCGATCAGAAAAT
TACCATTGCCAGAGCCAATAGATACCTACATTTCTAGTCGTATGGTGCAGTTAGATATGCGATATTTAGAAATCAAAGCA
CCTCATGCACTGCGATCATCTGCATTGCCATTACATCATCGAGATCCCTTTGATCGTATGTTGATTGCTCAGGCTCAAAT
TGAGAATATGACGCTGGTGAGTGCTGATTCAATATTCAAGCAATACAGCGATATTTCTGTTCTTTGGGCTGCTAATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237783 WP_002456349.1 NZ_CP093198:1069993-1070592 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237783 NZ_LR882944:258956-259201 [Planktothrix agardhii]
ATGGCTAAACTTCAGATTGAAAACTTACCCAACGACTTCAAAAAAAATCTCTCTGAGTTATTGTCTCGTGTAGAACTTGG
AGAAGAAATTATTATTTCCAATCAAGGGGTGGCGATCGCGAAGTTAATTCCGTTTCGTCCTTCATCCAATCGACGGGCGA
GTTTAGGGCAAGATCAAGGTAAATTTATCATACCAGACGACTTTAATGAACCGTTACCCCAAGAAATTTTGGCAGCATTT
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References