232131

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 970338..971140 Replicon chromosome
Accession NZ_CP090915
Organism Staphylococcus epidermidis strain 45A5

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KB229_RS04705 Protein ID WP_002468490.1
Coordinates 970961..971140 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KB229_RS04700 Protein ID WP_002456349.1
Coordinates 970338..970937 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB229_RS04675 (KB229_04675) 965549..967006 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KB229_RS04680 (KB229_04680) 966999..967721 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KB229_RS04685 (KB229_04685) 968236..968373 + 138 WP_162152359.1 hypothetical protein -
KB229_RS04690 (KB229_04690) 968583..969713 + 1131 WP_234966394.1 tRNA epoxyqueuosine(34) reductase QueG -
KB229_RS04695 (KB229_04695) 969710..970180 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KB229_RS04700 (KB229_04700) 970338..970937 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KB229_RS04705 (KB229_04705) 970961..971140 + 180 WP_002468490.1 SAS053 family protein Toxin
KB229_RS04710 (KB229_04710) 971296..971700 + 405 WP_001829818.1 hypothetical protein -
KB229_RS04715 (KB229_04715) 971885..973270 + 1386 WP_001829862.1 class II fumarate hydratase -
KB229_RS04720 (KB229_04720) 973631..974455 - 825 WP_002468488.1 RluA family pseudouridine synthase -
KB229_RS04725 (KB229_04725) 974614..975747 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 968218..968373 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T232131 WP_002468490.1 NZ_CP090915:970961-971140 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T232131 NZ_CP127273:362784-363086 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT232131 WP_002456349.1 NZ_CP090915:970338-970937 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT232131 NZ_CP127273:363134-363355 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References