200460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 737396..738198 Replicon chromosome
Accession NZ_CP073883
Organism Staphylococcus epidermidis strain B1287175

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV54_RS04040 Protein ID WP_002468490.1
Coordinates 738019..738198 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV54_RS04035 Protein ID WP_002456349.1
Coordinates 737396..737995 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV54_RS04010 (KFV54_04010) 732607..734064 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV54_RS04015 (KFV54_04015) 734057..734779 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV54_RS04020 (KFV54_04020) 735294..735431 + 138 WP_064783702.1 hypothetical protein -
KFV54_RS04025 (KFV54_04025) 735641..736771 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV54_RS04030 (KFV54_04030) 736768..737238 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV54_RS04035 (KFV54_04035) 737396..737995 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV54_RS04040 (KFV54_04040) 738019..738198 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV54_RS04045 (KFV54_04045) 738354..738758 + 405 WP_001829818.1 hypothetical protein -
KFV54_RS04050 (KFV54_04050) 738943..740328 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV54_RS04055 (KFV54_04055) 740689..741512 - 824 Protein_768 RluA family pseudouridine synthase -
KFV54_RS04060 (KFV54_04060) 741671..742804 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735276..735431 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200460 WP_002468490.1 NZ_CP073883:738019-738198 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200460 NZ_CP097881:c4038203-4037853 [Escherichia coli str. K-12 substr. MG1655]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200460 WP_002456349.1 NZ_CP073883:737396-737995 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200460 NZ_CP097881:c4038448-4038197 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References