Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1024305..1025107 Replicon chromosome
Accession NZ_CP073890
Organism Staphylococcus epidermidis strain V1933793

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV31_RS05535 Protein ID WP_002468490.1
Coordinates 1024928..1025107 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV31_RS05530 Protein ID WP_002456349.1
Coordinates 1024305..1024904 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV31_RS05505 (KFV31_05505) 1019516..1020973 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV31_RS05510 (KFV31_05510) 1020966..1021688 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV31_RS05515 (KFV31_05515) 1022203..1022340 + 138 WP_064783702.1 hypothetical protein -
KFV31_RS05520 (KFV31_05520) 1022550..1023680 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV31_RS05525 (KFV31_05525) 1023677..1024147 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV31_RS05530 (KFV31_05530) 1024305..1024904 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV31_RS05535 (KFV31_05535) 1024928..1025107 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV31_RS05540 (KFV31_05540) 1025263..1025667 + 405 WP_001829818.1 hypothetical protein -
KFV31_RS05545 (KFV31_05545) 1025852..1027237 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV31_RS05550 (KFV31_05550) 1027598..1028421 - 824 Protein_1034 RluA family pseudouridine synthase -
KFV31_RS05555 (KFV31_05555) 1028580..1029713 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1022185..1022340 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200470 WP_002468490.1 NZ_CP073890:1024928-1025107 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200470 NZ_CP097882:1779061-1779312 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200470 WP_002456349.1 NZ_CP073890:1024305-1024904 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200470 NZ_CP097882:1779309-1779563 [Escherichia coli str. K-12 substr. MG1655]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References