Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1618777..1619579 Replicon chromosome
Accession NZ_CP093179
Organism Staphylococcus epidermidis strain TMDU-190

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU31_RS07760 Protein ID WP_002468490.1
Coordinates 1618777..1618956 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU31_RS07765 Protein ID WP_002456349.1
Coordinates 1618980..1619579 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU31_RS07740 (MNU31_07745) 1614170..1615303 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
MNU31_RS07745 (MNU31_07750) 1615462..1616286 + 825 WP_254104734.1 RluA family pseudouridine synthase -
MNU31_RS07750 (MNU31_07755) 1616647..1618032 - 1386 WP_001829862.1 class II fumarate hydratase -
MNU31_RS07755 (MNU31_07760) 1618217..1618621 - 405 WP_001829818.1 hypothetical protein -
MNU31_RS07760 (MNU31_07765) 1618777..1618956 - 180 WP_002468490.1 SAS053 family protein Toxin
MNU31_RS07765 (MNU31_07770) 1618980..1619579 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU31_RS07770 (MNU31_07775) 1619737..1620207 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU31_RS07775 (MNU31_07780) 1620204..1621334 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU31_RS07780 (MNU31_07785) 1621544..1621681 - 138 WP_064783702.1 hypothetical protein -
MNU31_RS07785 (MNU31_07790) 1622196..1622918 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU31_RS07790 (MNU31_07795) 1622911..1624368 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1621544..1621699 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237753 WP_002468490.1 NZ_CP093179:c1618956-1618777 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237753 NZ_LR882500:2872332-2872709 [Mycobacterium tuberculosis variant microti]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237753 WP_002456349.1 NZ_CP093179:c1619579-1618980 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237753 NZ_LR882500:2872078-2872335 [Mycobacterium tuberculosis variant microti]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References