Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 739283..740085 Replicon chromosome
Accession NZ_CP070057
Organism Staphylococcus epidermidis strain FDAARGOS_1361

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag I6K91_RS03325 Protein ID WP_002468490.1
Coordinates 739283..739462 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag I6K91_RS03330 Protein ID WP_002456349.1
Coordinates 739486..740085 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K91_RS03305 734676..735809 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
I6K91_RS03310 735968..736792 + 825 WP_001829804.1 RluA family pseudouridine synthase -
I6K91_RS03315 737153..738538 - 1386 WP_001829862.1 class II fumarate hydratase -
I6K91_RS03320 738723..739127 - 405 WP_001829818.1 hypothetical protein -
I6K91_RS03325 739283..739462 - 180 WP_002468490.1 hypothetical protein Toxin
I6K91_RS03330 739486..740085 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
I6K91_RS03335 740243..740713 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I6K91_RS03340 740710..741840 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
I6K91_RS03345 742050..742187 - 138 WP_064783702.1 hypothetical protein -
I6K91_RS03350 742702..743424 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
I6K91_RS03355 743417..744874 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 742050..742205 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T192860 WP_002468490.1 NZ_CP070057:c739462-739283 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T192860 NZ_CP092565:c2123788-2123579 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT192860 WP_002456349.1 NZ_CP070057:c740085-739486 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT192860 NZ_CP092565:c2124093-2123800 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References