Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 975343..976145 Replicon chromosome
Accession NZ_CP093165
Organism Staphylococcus epidermidis strain TMDU-41

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag MNU56_RS04685 Protein ID WP_002468490.1
Coordinates 975966..976145 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag MNU56_RS04680 Protein ID WP_002456349.1
Coordinates 975343..975942 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU56_RS04655 (MNU56_04650) 970554..972011 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
MNU56_RS04660 (MNU56_04655) 972004..972726 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
MNU56_RS04665 (MNU56_04660) 973241..973378 + 138 WP_064783702.1 hypothetical protein -
MNU56_RS04670 (MNU56_04665) 973588..974718 + 1131 WP_254104122.1 tRNA epoxyqueuosine(34) reductase QueG -
MNU56_RS04675 (MNU56_04670) 974715..975185 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MNU56_RS04680 (MNU56_04675) 975343..975942 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
MNU56_RS04685 (MNU56_04680) 975966..976145 + 180 WP_002468490.1 SAS053 family protein Toxin
MNU56_RS04690 (MNU56_04685) 976301..976705 + 405 WP_001829818.1 hypothetical protein -
MNU56_RS04695 (MNU56_04690) 976890..978275 + 1386 WP_001829862.1 class II fumarate hydratase -
MNU56_RS04700 (MNU56_04695) 978636..979460 - 825 WP_001829804.1 RluA family pseudouridine synthase -
MNU56_RS04705 (MNU56_04700) 979619..980752 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 973223..973378 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T237740 WP_002468490.1 NZ_CP093165:975966-976145 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T237740 NZ_LR882500:c2208545-2208216 [Mycobacterium tuberculosis variant microti]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT237740 WP_002456349.1 NZ_CP093165:975343-975942 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT237740 NZ_LR882500:c2208919-2208542 [Mycobacterium tuberculosis variant microti]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References