200455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1024205..1025007 Replicon chromosome
Accession NZ_CP073881
Organism Staphylococcus epidermidis strain B1286247

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag KFV53_RS05495 Protein ID WP_002468490.1
Coordinates 1024828..1025007 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag KFV53_RS05490 Protein ID WP_002456349.1
Coordinates 1024205..1024804 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV53_RS05465 (KFV53_05465) 1019416..1020873 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
KFV53_RS05470 (KFV53_05470) 1020866..1021588 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
KFV53_RS05475 (KFV53_05475) 1022103..1022240 + 138 WP_064783702.1 hypothetical protein -
KFV53_RS05480 (KFV53_05480) 1022450..1023580 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
KFV53_RS05485 (KFV53_05485) 1023577..1024047 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KFV53_RS05490 (KFV53_05490) 1024205..1024804 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
KFV53_RS05495 (KFV53_05495) 1024828..1025007 + 180 WP_002468490.1 SAS053 family protein Toxin
KFV53_RS05500 (KFV53_05500) 1025163..1025567 + 405 WP_001829818.1 hypothetical protein -
KFV53_RS05505 (KFV53_05505) 1025752..1027137 + 1386 WP_001829862.1 class II fumarate hydratase -
KFV53_RS05510 (KFV53_05510) 1027498..1028321 - 824 Protein_1034 RluA family pseudouridine synthase -
KFV53_RS05515 (KFV53_05515) 1028480..1029613 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1022085..1022240 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T200455 WP_002468490.1 NZ_CP073881:1024828-1025007 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T200455 NZ_CP097881:3582351-3582692 [Escherichia coli str. K-12 substr. MG1655]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT200455 WP_002456349.1 NZ_CP073881:1024205-1024804 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT200455 NZ_CP097881:3582013-3582330 [Escherichia coli str. K-12 substr. MG1655]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References