Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4242704..4243335 Replicon chromosome
Accession NZ_CP037923
Organism Shigella flexneri 5a str. M90T

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag EKN05_RS21610 Protein ID WP_001259385.1
Coordinates 4242704..4242979 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag EKN05_RS21615 Protein ID WP_000593555.1
Coordinates 4242976..4243335 (+) Length 120 a.a.

Genomic Context

EKN05_RS21595EKN05_RS21600EKN05_RS21605EKN05_RS21610EKN05_RS21615EKN05_RS21620EKN05_RS21625EKN05_RS21630EKN05_RS21635EKN05_RS21640
Location: 4237722..4238789 (1068 bp)
Type: Others
Protein ID: WP_000361470.1
Location: 4238786..4241521 (2736 bp)
Type: Others
Protein ID: WP_000149171.1
Location: 4241521..4242645 (1125 bp)
Type: Others
Protein ID: WP_001216257.1
Location: 4242704..4242979 (276 bp)
Type: Toxin
Protein ID: WP_001259385.1
Location: 4242976..4243335 (360 bp)
Type: Antitoxin
Protein ID: WP_000593555.1
Location: 4243455..4243856 (402 bp)
Type: Others
Protein ID: WP_001190062.1
Location: 4243862..4244668 (807 bp)
Type: Others
Protein ID: WP_000173670.1
Location: 4244665..4245429 (765 bp)
Type: Others
Protein ID: WP_001136248.1
Location: 4245429..4246262 (834 bp)
Type: Others
Protein ID: WP_001008974.1
Location: 4246259..4247203 (945 bp)
Type: Others
Protein ID: WP_000947077.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EKN05_RS21595 (EKN05_021600)4237722..4238789+1068WP_000361470.1HlyD family secretion protein-
EKN05_RS21600 (EKN05_021605)4238786..4241521+2736WP_000149171.1ribosome-associated ATPase/putative transporter RbbA-
EKN05_RS21605 (EKN05_021610)4241521..4242645+1125WP_001216257.1ABC transporter permease-
EKN05_RS21610 (EKN05_021615)4242704..4242979+276WP_001259385.1type II toxin-antitoxin system HicA family toxinToxin
EKN05_RS21615 (EKN05_021620)4242976..4243335+360WP_000593555.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
EKN05_RS21620 (EKN05_021625)4243455..4243856-402WP_001190062.1nickel-responsive transcriptional regulator NikR-
EKN05_RS21625 (EKN05_021630)4243862..4244668-807WP_000173670.1nickel import ATP-binding protein NikE-
EKN05_RS21630 (EKN05_021635)4244665..4245429-765WP_001136248.1nickel import ATP-binding protein NikD-
EKN05_RS21635 (EKN05_021640)4245429..4246262-834WP_001008974.1nickel ABC transporter permease subunit NikC-
EKN05_RS21640 (EKN05_021645)4246259..4247203-945WP_000947077.1nickel ABC transporter permease subunit NikB-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideGenomic island--4222298..424333521037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T120378 WP_001259385.1 NZ_CP037923:4242704-4242979 [Shigella flexneri 5a str. M90T]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T120378 NZ_CP037923:4242704-4242979 [Shigella flexneri 5a str. M90T]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT120378 WP_000593555.1 NZ_CP037923:4242976-4243335 [Shigella flexneri 5a str. M90T]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT120378 NZ_CP037923:4242976-4243335 [Shigella flexneri 5a str. M90T]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A4P7TTW8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7U9LKZ6

References